The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study Approaches to control rate in atrial fibrillation
Olshansky B, Rosenfeld LE, Warner AL, Solomon AJ, O'Neill G, Sharma A, Platia E, Feld GK, Akiyama T, Brodsky MA, Greene HL, Investigators A. The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study Approaches to control rate in atrial fibrillation. Journal Of The American College Of Cardiology 2004, 43: 1201-1208. PMID: 15063430, DOI: 10.1016/j.jacc.2003.11.032.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAnti-Arrhythmia AgentsAtrial FibrillationCalcium Channel BlockersCatheter AblationDigoxinDrug Therapy, CombinationElectrocardiography, AmbulatoryFemaleFollow-Up StudiesHeart RateHumansMaleMiddle AgedMultivariate AnalysisPacemaker, ArtificialStroke VolumeTreatment OutcomeConceptsCalcium channel blockersAtrial Fibrillation FollowAtrial fibrillationChannel blockersAFFIRM studyDrug classesFirst drugAdequate rate controlFirst drug classFrequent medication changesRhythm Management (AFFIRM) studyMajority of patientsBeta-adrenergic blockersRate control drugsElectrocardiographic resultsMedication changesWalk testInitial treatmentClinical variablesEfficacy criteriaDrug combinationsHeart rateEffective drugsPatientsMultivariate analysis