Keratin 17 is a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma
Delgado-Coka L, Roa-Peña L, Babu S, Horowitz M, Petricoin E, Matrisian L, Blais E, Marchenko N, Allard F, Akalin A, Jiang W, Larson B, Hendifar A, Picozzi V, Choi M, Shroyer K, Escobar-Hoyos L. Keratin 17 is a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma. American Journal Of Clinical Pathology 2024, 162: 314-326. PMID: 38642081, PMCID: PMC11369068, DOI: 10.1093/ajcp/aqae038.Peer-Reviewed Original ResearchPancreatic ductal adenocarcinomaPredictive biomarkersDuctal adenocarcinomaK17 expressionKeratin 17Gemcitabine-based therapyGemcitabine-based chemotherapyBasal molecular subtypeTumor mutation statusResponse to chemotherapyPancreatic ductal adenocarcinoma cellsThreshold of expressionChemotherapeutic regimensAdvanced-stageClinicopathological variablesMutation statusPrognostic stratificationMolecular subtypesShorter survivalLonger survivalFormalin-fixedImmunohistochemical testsPredictive valuePatientsTherapeutic interventions