2009
The fifth class of Gα proteins
Oka Y, Saraiva L, Kwan Y, Korsching S. The fifth class of Gα proteins. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 1484-1489. PMID: 19164534, PMCID: PMC2635825, DOI: 10.1073/pnas.0809420106.Peer-Reviewed Original ResearchConceptsBirth-and-death mode of evolutionCharacteristics of GTP-binding proteinsGalpha proteinsVertebrate family membersAmino acid identityGTP-binding proteinsHeterotrimeric G proteinsN-terminal regionMode of evolutionAmino acid residuesG-boxGenomic structureAcid identityAnimal phylaConsensus sitesRT-PCR analysisGV proteinsJawless fishAcid residuesGA proteinsAnimal kingdomLarval tissuesAlpha subunitPartner moleculesFruit fly
2008
Structural and functional diversification in the teleost S100 family of calcium-binding proteins
Kraemer A, Saraiva L, Korsching S. Structural and functional diversification in the teleost S100 family of calcium-binding proteins. BMC Ecology And Evolution 2008, 8: 48. PMID: 18275604, PMCID: PMC2266712, DOI: 10.1186/1471-2148-8-48.Peer-Reviewed Original ResearchConceptsS100 genesS100 gene familyGene familyJawless fishEF-handPatterns of gene gainCartilaginous fishCalcium-binding proteinLocal gene duplicationS100 familyMammalian family membersCell typesCalcium-mediated signalingEF-hand calcium-binding proteinS100 family membersGenomic arrangementTeleost genomesIntron/exon bordersGene lossGene duplicationGene gainFunctional diversificationS100 subfamilyFamily membersEvolutionary origin