Featured Publications
High-affinity olfactory receptor for the death-associated odor cadaverine
Hussain A, Saraiva L, Ferrero D, Ahuja G, Krishna V, Liberles S, Korsching S. High-affinity olfactory receptor for the death-associated odor cadaverine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 19579-19584. PMID: 24218586, PMCID: PMC3845148, DOI: 10.1073/pnas.1318596110.Peer-Reviewed Original ResearchConceptsInnate behaviorsOlfactory receptorsSocial cuesOlfactory sensory neuronsNeural circuitsDetect cadaverineCarrion smellsVertebrate olfactionSensory neuronsAmino acids ornithinePhysiologically relevant sourceReceptorsConcomitant activationMolecular basisConcentration of cadaverineTAAR13cNeuronsSpeciesCuesOlfactionBehaviorSmellCadaverinePositive Darwinian selection and the birth of an olfactory receptor clade in teleosts
Hussain A, Saraiva L, Korsching S. Positive Darwinian selection and the birth of an olfactory receptor clade in teleosts. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 4313-4318. PMID: 19237578, PMCID: PMC2657432, DOI: 10.1073/pnas.0803229106.Peer-Reviewed Original ResearchConceptsTrace amine-associated receptorsTAAR genesIntron gainGene familyClass IIIBony fishesOlfactory receptor neuronsPositive Darwinian selectionLocal positive selectionOlfactory receptor gene familyClass III genesOlfactory receptorsOlfactory receptor familyReceptor gene familyOlfactory epitheliumLigand-binding motifsFish genesTeleost lineageReceptor neuronsJawless vertebratesVertebrate evolutionIII genesPositive selectionDarwinian selectionEvolutionary dynamicsA novel olfactory receptor gene family in teleost fish
Saraiva L, Korsching S. A novel olfactory receptor gene family in teleost fish. Genome Research 2007, 17: 1448-1457. PMID: 17717047, PMCID: PMC1987349, DOI: 10.1101/gr.6553207.Peer-Reviewed Original ResearchConceptsOra genesGene pairsMulti-exon structureSpecies-specific expansionOlfactory receptor gene familyV1R-like genesOlfactory receptor familyReceptor gene familySpeciation eventsTeleost lineagePhylogenetic treePhylogenetic analysisGene familyGene regulationGene repertoireGene functionOlfactory epithelium of zebrafishTeleost familiesTeleost speciesOrthologsTeleost fishGenesNegative selectionTeleostFish species
2015
Molecular and neuronal homology between the olfactory systems of zebrafish and mouse
Saraiva L, Ahuja G, Ivandic I, Syed A, Marioni J, Korsching S, Logan D. Molecular and neuronal homology between the olfactory systems of zebrafish and mouse. Scientific Reports 2015, 5: 11487. PMID: 26108469, PMCID: PMC4480006, DOI: 10.1038/srep11487.Peer-Reviewed Original ResearchConceptsDegree of molecular conservationYears of evolutionary divergenceVomeronasal organOlfactory mucosaOlfactory organChemosensory receptor genesOlfactory systemTranscriptome of miceDual olfactory systemEvolutionary divergenceMolecular conservationNeuronal homologRepertoire sizeRNA abundanceMolecular relationshipsCell-specific markersClasses of neuronsMolecular basisChemosensory receptorsMarker genesOrgans of rodentsAbsolute abundanceZebrafishReceptor geneVertebrates
2009
The fifth class of Gα proteins
Oka Y, Saraiva L, Kwan Y, Korsching S. The fifth class of Gα proteins. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 1484-1489. PMID: 19164534, PMCID: PMC2635825, DOI: 10.1073/pnas.0809420106.Peer-Reviewed Original ResearchConceptsBirth-and-death mode of evolutionCharacteristics of GTP-binding proteinsGalpha proteinsVertebrate family membersAmino acid identityGTP-binding proteinsHeterotrimeric G proteinsN-terminal regionMode of evolutionAmino acid residuesG-boxGenomic structureAcid identityAnimal phylaConsensus sitesRT-PCR analysisGV proteinsJawless fishAcid residuesGA proteinsAnimal kingdomLarval tissuesAlpha subunitPartner moleculesFruit fly
2008
Structural and functional diversification in the teleost S100 family of calcium-binding proteins
Kraemer A, Saraiva L, Korsching S. Structural and functional diversification in the teleost S100 family of calcium-binding proteins. BMC Ecology And Evolution 2008, 8: 48. PMID: 18275604, PMCID: PMC2266712, DOI: 10.1186/1471-2148-8-48.Peer-Reviewed Original ResearchConceptsS100 genesS100 gene familyGene familyJawless fishEF-handPatterns of gene gainCartilaginous fishCalcium-binding proteinLocal gene duplicationS100 familyMammalian family membersCell typesCalcium-mediated signalingEF-hand calcium-binding proteinS100 family membersGenomic arrangementTeleost genomesIntron/exon bordersGene lossGene duplicationGene gainFunctional diversificationS100 subfamilyFamily membersEvolutionary origin