SysInflam HuDB, a Web Resource for Mining Human Blood Cells Transcriptomic Data Associated with Systemic Inflammatory Responses to Sepsis
Toufiq M, Huang S, Boughorbel S, Alfaki M, Rinchai D, Saraiva L, Chaussabel D, Garand M. SysInflam HuDB, a Web Resource for Mining Human Blood Cells Transcriptomic Data Associated with Systemic Inflammatory Responses to Sepsis. The Journal Of Immunology 2021, 207: 2195-2202. PMID: 34663591, PMCID: PMC8525868, DOI: 10.4049/jimmunol.2100697.Peer-Reviewed Original ResearchConceptsPublic transcriptome dataGene expression changesTranscriptome dataTranscriptomic datasetsBlood transcriptome datasetsSystemic inflammatory response to sepsisDisease susceptibilityResponse to infectionBlood gene signaturesExpression changesClinical metadataHost inflammatory responseInflammatory responseSystemic infectionDysregulated host inflammatory responseInflammatory response to sepsisGene signatureSystemic inflammatory responseMechanistic discoveriesSystemic inflammatory diseaseResponse to sepsisHeterogeneous diseaseWeb-based interfaceSepsis biomarkersInflammatory diseasesTranscriptome and Literature Mining Highlight the Differential Expression of ERLIN1 in Immune Cells during Sepsis
Huang S, Toufiq M, Saraiva L, Van Panhuys N, Chaussabel D, Garand M. Transcriptome and Literature Mining Highlight the Differential Expression of ERLIN1 in Immune Cells during Sepsis. Biology 2021, 10: 755. PMID: 34439987, PMCID: PMC8389572, DOI: 10.3390/biology10080755.Peer-Reviewed Original ResearchImmune cellsFatty acid biosynthesisWhole blood of healthy volunteersBlood of healthy volunteersMembrane protein componentsBlood cell subsetsWhole blood neutrophilsWhole bloodIn vitro expressionAcid biosynthesisHost immune systemHL60 cell lineER functionTranscriptomic datasetsCombination of lipopolysaccharideERLIN1Sepsis literatureSeptic stimulationCellular perturbationsCell subsetsProtein componentsHealthy volunteersDifferential expressionSepsisSeptic conditions