2024
Lung function and health-related quality of life among adult patients following pulmonary TB treatment.
Zawedde J, Abelman R, Musisi E, Nyabigambo A, Sanyu I, Kaswabuli S, Byanyima P, Lewis E, Sessolo A, Lalitha R, Kiwanuka N, Crothers K, Worodria W, Davis J, Huang L. Lung function and health-related quality of life among adult patients following pulmonary TB treatment. The International Journal Of Tuberculosis And Lung Disease 2024, 28: 419-426. PMID: 39187999, DOI: 10.5588/ijtld.24.0029.Peer-Reviewed Original ResearchConceptsSt. George's Respiratory QuestionnaireQuality of lifeAbnormal lung functionSpirometric restrictionHealth-related quality of lifeLung functionPost-TB lung diseaseHealth-related qualityFemale sexRisk factorsFunctional abnormalitiesGeorge's Respiratory QuestionnairePTB treatmentPulmonary TB treatmentAssociated with increased morbidityChronic lung complicationsPrevalence ratiosResource-limited settingsChest X-rayLung function abnormalitiesRespiratory QuestionnaireSGRQ scoreAssociated with lung function abnormalitiesSmoking statusBilateral consolidation
2015
Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis
Walter ND, Dolganov GM, Garcia BJ, Worodria W, Andama A, Musisi E, Ayakaka I, Van TT, Voskuil MI, de Jong BC, Davidson RM, Fingerlin TE, Kechris K, Palmer C, Nahid P, Daley CL, Geraci M, Huang L, Cattamanchi A, Strong M, Schoolnik GK, Davis JL. Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis. The Journal Of Infectious Diseases 2015, 212: 990-998. PMID: 25762787, PMCID: PMC4548467, DOI: 10.1093/infdis/jiv149.Peer-Reviewed Original ResearchConceptsDrug-tolerant bacilliDrug exposureDrug-susceptible pulmonary tuberculosisDrug-tolerant Mycobacterium tuberculosisDrug-susceptible Mycobacterium tuberculosisMycobacterium tuberculosisTuberculosis treatment regimensInitial drug exposureReverse transcription-polymerase chain reactionMessenger RNA expressionM. tuberculosis gene expressionDrug efflux pumpsSerial sputaPulmonary tuberculosisTreatment initiationNovel drug targetsTreatment regimensPolymerase chain reactionToxin-antitoxin genesHuman tuberculosisRate of declineDrug responsivenessStress signatureMarked downregulationDrug tolerance