2017
Bringing patient-centered tuberculosis diagnosis into the light of day
Davis JL. Bringing patient-centered tuberculosis diagnosis into the light of day. BMC Medicine 2017, 15: 219. PMID: 29258526, PMCID: PMC5738029, DOI: 10.1186/s12916-017-0992-4.Peer-Reviewed Original ResearchConceptsSmear microscopySame-day sputum smear microscopyTB diagnostic toolsPatient-centered TB careEnd TB Strategy goalsPatient-centered careSputum smear microscopyPatient-centered servicesTuberculosis deathsTB careTB StrategyTuberculosis diagnosisDiagnostic careCatastrophic costsRecent evidenceCareDiagnostic toolRelated articles
2015
Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis
Walter ND, Dolganov GM, Garcia BJ, Worodria W, Andama A, Musisi E, Ayakaka I, Van TT, Voskuil MI, de Jong BC, Davidson RM, Fingerlin TE, Kechris K, Palmer C, Nahid P, Daley CL, Geraci M, Huang L, Cattamanchi A, Strong M, Schoolnik GK, Davis JL. Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis. The Journal Of Infectious Diseases 2015, 212: 990-998. PMID: 25762787, PMCID: PMC4548467, DOI: 10.1093/infdis/jiv149.Peer-Reviewed Original ResearchConceptsDrug-tolerant bacilliDrug exposureDrug-susceptible pulmonary tuberculosisDrug-tolerant Mycobacterium tuberculosisDrug-susceptible Mycobacterium tuberculosisMycobacterium tuberculosisTuberculosis treatment regimensInitial drug exposureReverse transcription-polymerase chain reactionMessenger RNA expressionM. tuberculosis gene expressionDrug efflux pumpsSerial sputaPulmonary tuberculosisTreatment initiationNovel drug targetsTreatment regimensPolymerase chain reactionToxin-antitoxin genesHuman tuberculosisRate of declineDrug responsivenessStress signatureMarked downregulationDrug tolerance