2023
Geographic distribution and predictors of diagnostic delays among possible TB patients in Uganda
Ochom E, Robsky K, Gupta A, Tamale A, Kungu J, Turimumahoro P, Nakasendwa S, Rwego I, Muttamba W, Joloba M, Ssengooba W, Davis J, Katamba A. Geographic distribution and predictors of diagnostic delays among possible TB patients in Uganda. Public Health Action 2023, 13: 70-76. PMID: 37736583, PMCID: PMC10446659, DOI: 10.5588/pha.23.0010.Peer-Reviewed Original ResearchHealth system delayPatient delayTB evaluationDiagnostic delayHealth system-related delaysSystem-related delaysTB diagnostic delayMultivariate logistic regressionTB knowledgeTB patientsTB diagnosisPatient outcomesSecondary analysisLogistic regressionGlobal Moran's IMarital statusPatientsAdultsPredictorsIndividual predictorsMarried individualsIndividual factorsGeographic hotspotsYearsDiagnosisA user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial
Katamba A, Gupta A, Turimumahoro P, Ochom E, Ggita J, Nakasendwa S, Nanziri L, Musinguzi J, Hennein R, Sekadde M, Hanrahan C, Byaruhanga R, Yoeli E, Turyahabwe S, Cattamanchi A, Dowdy D, Haberer J, Armstrong-Hough M, Kiwanuka N, Davis J. A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial. BMC Public Health 2023, 23: 1568. PMID: 37592314, PMCID: PMC10436440, DOI: 10.1186/s12889-023-16510-0.Peer-Reviewed Original ResearchConceptsContact investigationClinical effectiveness outcomesPrimary implementation outcomeTB contact investigationTB preventative therapyTB treatment initiationTimely TB diagnosisTrial registrationThe trialTuberculosis contact investigationCluster-randomised trialHigh-burden settingsImplementation-effectiveness trialEvidence-based interventionsUganda National CouncilWorld Health OrganizationProportion of contactsTB evaluationPeer-reviewed journalsMiddle-income countriesTreatment initiationTB diagnosisPreventative therapyUndiagnosed personsInfectious deathSputum samples
2022
Feasibility and Sensitivity of Saliva GeneXpert MTB/RIF Ultra for Tuberculosis Diagnosis in Adults in Uganda
Byanyima P, Kaswabuli S, Musisi E, Nabakiibi C, Zawedde J, Sanyu I, Sessolo A, Andama A, Worodria W, Huang L, Davis JL. Feasibility and Sensitivity of Saliva GeneXpert MTB/RIF Ultra for Tuberculosis Diagnosis in Adults in Uganda. Microbiology Spectrum 2022, 10: e00860-22. PMID: 36154664, PMCID: PMC9603304, DOI: 10.1128/spectrum.00860-22.Peer-Reviewed Original ResearchConceptsGeneXpert MTB/RIF UltraMTB/RIF UltraXpert UltraTB diagnosisMolecular testingHigh TB burden settingsCulture-confirmed TB casesSaliva samplesTB diagnostic evaluationActive tuberculosis diseaseProspective observational studyActive TB diagnosisCause of morbidityAcid-fast bacilliComposite reference standardReference standardCase-only studySingle saliva sampleWorld Health OrganizationSpot sputumTB evaluationConsecutive adultsTB casesBurden settingsOutpatient department
2021
Evaluating the Quality of Tuberculosis Contact Investigation in Cali, Colombia: A Retrospective Cohort Study.
Diaz G, Victoria AM, Meyer AJ, Niño Y, Luna L, Ferro BE, Davis J. Evaluating the Quality of Tuberculosis Contact Investigation in Cali, Colombia: A Retrospective Cohort Study. American Journal Of Tropical Medicine And Hygiene 2021, 104: 1309-1316. PMID: 33617470, PMCID: PMC8045602, DOI: 10.4269/ajtmh.20-0809.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyTuberculosis contact investigationContact investigationTB patientsHousehold visitsTB evaluationClinic visitsCohort studyEarly TB diagnosisIndex TB patientsTB contact investigationActive TB patientsTherapy initiationPreventive therapyTB diagnosisSymptomatic contactsMultivariable modelClinic referralsIndex patientsPatientsContact tracingVisitsCumulative probabilityLittle dataReferral