1995
Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system
Ortiz J, Fitzgerald L, Charlton M, Lane S, Trevisan L, Guitart X, Shoemaker W, Duman R, Nestler E. Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse 1995, 21: 289-298. PMID: 8869159, DOI: 10.1002/syn.890210403.Peer-Reviewed Original ResearchConceptsVentral tegmental areaChronic ethanol exposure resultsMesolimbic dopamine systemChronic ethanol treatmentEthanol exposure resultsAction of ethanolDopamine systemEthanol exposureNucleus accumbensGlutamate receptorsProtein immunoreactivityTyrosine hydroxylaseNeural pathwaysGlial fibrillary acidic protein immunoreactivityEthanol treatmentLong-term ethanol exposureNigrostriatal dopamine systemChronic ethanol exposureExposure resultsNMDA glutamate receptorsTyrosine hydroxylase expressionAMPA glutamate receptorsGABAA receptor complexLevels of immunoreactivityNeurofilament protein immunoreactivity
1994
Rapid Communication Chronic Ingestion of Ethanol Up‐Regulates NMDAR1 Receptor Subunit Immunoreactivity in Rat Hippocampus
Trevisan L, Fitzgerald L, Brose N, Gasic G, Heinemann S, Duman R, Nestler E. Rapid Communication Chronic Ingestion of Ethanol Up‐Regulates NMDAR1 Receptor Subunit Immunoreactivity in Rat Hippocampus. Journal Of Neurochemistry 1994, 62: 1635-1638. PMID: 8133290, DOI: 10.1046/j.1471-4159.1994.62041635.x.Peer-Reviewed Original ResearchConceptsChronic ethanol exposureSubunit immunoreactivityEthanol exposureGlutamate receptorsIsoxazole propionic acid (AMPA) glutamate receptorsPropionic acid glutamate receptorsImportant neurochemical substrateReceptor subunit immunoreactivityGlutamate receptor subunit 1Different neurotransmitter systemsAspartate glutamate receptorsDifferent pharmacological profilesReceptor subunit 1Effects of ethanolChronic administrationChronic treatmentNMDAR1 immunoreactivityCerebral cortexChronic ingestionEthanol dependenceGluR2 proteinRat hippocampusNeurotransmitter systemsNMDAR1 subunitNucleus accumbensSecond Messenger and Protein Phosphorylation Mechanisms Underlying Possible Genetic Vulnerability to Alcoholisma
NESTLER E, GUITART X, ORTIZ J, TREVISAN L. Second Messenger and Protein Phosphorylation Mechanisms Underlying Possible Genetic Vulnerability to Alcoholisma. Annals Of The New York Academy Of Sciences 1994, 708: 108-118. PMID: 8154671, DOI: 10.1111/j.1749-6632.1994.tb24703.x.Peer-Reviewed Original Research