2010
Characterization of the Interactive Effects of Glycine and D-Cycloserine in Men: Further Evidence for Enhanced NMDA Receptor Function Associated with Human Alcohol Dependence
Krystal JH, Petrakis IL, Limoncelli D, Nappi SK, Trevisan L, Pittman B, D'Souza DC. Characterization of the Interactive Effects of Glycine and D-Cycloserine in Men: Further Evidence for Enhanced NMDA Receptor Function Associated with Human Alcohol Dependence. Neuropsychopharmacology 2010, 36: 701-710. PMID: 21124304, PMCID: PMC3055693, DOI: 10.1038/npp.2010.203.Peer-Reviewed Original ResearchConceptsNMDA receptor functionAlcohol-dependent patientsHuman alcohol dependenceAntagonist-like effectsReceptor functionReceptor antagonistDCS effectsD-cycloserineAlcohol-like effectsAlcohol dependenceNMDA glutamate receptor functionN-methyl-D-aspartate (NMDA) glutamate receptor antagonistStandard alcohol drinksGlutamate receptor antagonistsChronic alcohol consumptionDouble-blind conditionsNMDA receptor antagonistAlcohol-dependent menGlutamate receptor functionAlcohol-dependent animalsPlasma levelsGlycine administrationGlycine levelsNMDA receptorsCoagonist site
1995
Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system
Ortiz J, Fitzgerald L, Charlton M, Lane S, Trevisan L, Guitart X, Shoemaker W, Duman R, Nestler E. Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse 1995, 21: 289-298. PMID: 8869159, DOI: 10.1002/syn.890210403.Peer-Reviewed Original ResearchConceptsVentral tegmental areaChronic ethanol exposure resultsMesolimbic dopamine systemChronic ethanol treatmentEthanol exposure resultsAction of ethanolDopamine systemEthanol exposureNucleus accumbensGlutamate receptorsProtein immunoreactivityTyrosine hydroxylaseNeural pathwaysGlial fibrillary acidic protein immunoreactivityEthanol treatmentLong-term ethanol exposureNigrostriatal dopamine systemChronic ethanol exposureExposure resultsNMDA glutamate receptorsTyrosine hydroxylase expressionAMPA glutamate receptorsGABAA receptor complexLevels of immunoreactivityNeurofilament protein immunoreactivity