2007
Absence of Significant Interactive Effects of High‐Dose d‐Cycloserine and Ethanol in Healthy Human Subjects: Preliminary Insights Into Ethanol Actions at the GlycineB Site of NMDA Glutamate Receptors
Trevisan L, Petrakis IL, Pittman B, Gueorguieva R, D’Souza D, Perry E, Limoncelli D, Krystal JH. Absence of Significant Interactive Effects of High‐Dose d‐Cycloserine and Ethanol in Healthy Human Subjects: Preliminary Insights Into Ethanol Actions at the GlycineB Site of NMDA Glutamate Receptors. Alcohol Clinical And Experimental Research 2007, 32: 36-42. PMID: 18028532, DOI: 10.1111/j.1530-0277.2007.00543.x.Peer-Reviewed Original ResearchConceptsCo-agonist siteHealthy human subjectsEthanol administrationD-cycloserineHigh-dose d-cycloserineAlcohol levelsReceptor functionPlacebo 4 hoursDouble-blind conditionsNMDA receptor functionNMDA glutamate receptorsMild sedative effectDoses of ethanolGlutamate receptor functionBreath alcohol levelsHuman subjectsVerbal fluencyGlycineB siteGroups of subjectsEthanol antagonismCombination of ethanolSedative effectsNMDA receptorsClinical significanceGlutamate receptors
2003
N-methyl-d-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability
Krystal JH, Petrakis IL, Mason G, Trevisan L, D'Souza DC. N-methyl-d-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacology & Therapeutics 2003, 99: 79-94. PMID: 12804700, DOI: 10.1016/s0163-7258(03)00054-8.Peer-Reviewed Original ResearchConceptsGlutamatergic systemEthanol abuseGlutamate receptorsN-methyl-D-aspartate (NMDA) subtypePrimary excitatory neurotransmitterAspartate glutamate receptorsAction of ethanolEthanol withdrawalGlutamatergic agentsGlutamatergic functionExcitatory neurotransmitterTranslational neuroscience perspectiveGlutamate systemEthanol intoxicationBehavioral effectsEthanol contributeAlcoholismBrainReceptorsTreatmentAbuseN-methylSubtypesNeurotransmittersIntoxicationAltered NMDA Glutamate Receptor Antagonist Response in Recovering Ethanol-Dependent Patients
Krystal JH, Petrakis IL, Limoncelli D, Webb E, Gueorgueva R, D'Souza DC, Boutros NN, Trevisan L, Charney DS. Altered NMDA Glutamate Receptor Antagonist Response in Recovering Ethanol-Dependent Patients. Neuropsychopharmacology 2003, 28: 2020-2028. PMID: 12888778, DOI: 10.1038/sj.npp.1300252.Peer-Reviewed Original ResearchConceptsEthanol-dependent patientsNMDA receptor antagonistReceptor antagonistEthanol dependenceN-methyl-D-aspartate (NMDA) glutamate receptorsDouble-blind studySelective NMDA receptor antagonistNMDA receptor functionAlcohol-dependent patientsHealthy comparison subjectsTreatment of alcoholismHealthy comparison groupExecutive cognitive functionKetamine infusionKetamine 0.5NMDA receptorsGlutamate receptorsComparison subjectsPatientsAmnestic effectsRandomized orderReceptor functionCognitive functionAntagonist responseAntagonist
1995
Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system
Ortiz J, Fitzgerald L, Charlton M, Lane S, Trevisan L, Guitart X, Shoemaker W, Duman R, Nestler E. Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse 1995, 21: 289-298. PMID: 8869159, DOI: 10.1002/syn.890210403.Peer-Reviewed Original ResearchConceptsVentral tegmental areaChronic ethanol exposure resultsMesolimbic dopamine systemChronic ethanol treatmentEthanol exposure resultsAction of ethanolDopamine systemEthanol exposureNucleus accumbensGlutamate receptorsProtein immunoreactivityTyrosine hydroxylaseNeural pathwaysGlial fibrillary acidic protein immunoreactivityEthanol treatmentLong-term ethanol exposureNigrostriatal dopamine systemChronic ethanol exposureExposure resultsNMDA glutamate receptorsTyrosine hydroxylase expressionAMPA glutamate receptorsGABAA receptor complexLevels of immunoreactivityNeurofilament protein immunoreactivity
1994
Rapid Communication Chronic Ingestion of Ethanol Up‐Regulates NMDAR1 Receptor Subunit Immunoreactivity in Rat Hippocampus
Trevisan L, Fitzgerald L, Brose N, Gasic G, Heinemann S, Duman R, Nestler E. Rapid Communication Chronic Ingestion of Ethanol Up‐Regulates NMDAR1 Receptor Subunit Immunoreactivity in Rat Hippocampus. Journal Of Neurochemistry 1994, 62: 1635-1638. PMID: 8133290, DOI: 10.1046/j.1471-4159.1994.62041635.x.Peer-Reviewed Original ResearchConceptsChronic ethanol exposureSubunit immunoreactivityEthanol exposureGlutamate receptorsIsoxazole propionic acid (AMPA) glutamate receptorsPropionic acid glutamate receptorsImportant neurochemical substrateReceptor subunit immunoreactivityGlutamate receptor subunit 1Different neurotransmitter systemsAspartate glutamate receptorsDifferent pharmacological profilesReceptor subunit 1Effects of ethanolChronic administrationChronic treatmentNMDAR1 immunoreactivityCerebral cortexChronic ingestionEthanol dependenceGluR2 proteinRat hippocampusNeurotransmitter systemsNMDAR1 subunitNucleus accumbens