2009
How Common Is Diclofenac-Associated Liver Injury? Analysis of 17,289 Arthritis Patients in a Long-Term Prospective Clinical Trial
Laine L, Goldkind L, Curtis SP, Connors LG, Yanqiong Z, Cannon CP. How Common Is Diclofenac-Associated Liver Injury? Analysis of 17,289 Arthritis Patients in a Long-Term Prospective Clinical Trial. The American Journal Of Gastroenterology 2009, 104: ajg2008149. PMID: 19174782, DOI: 10.1038/ajg.2008.149.Peer-Reviewed Original ResearchConceptsLiver-related hospitalizationsNon-steroidal anti-inflammatory drugsMonths of therapyAminotransferase elevationLiver eventsClinical trialsLong-term prospective clinical trialsLarge double-blind trialDeath/transplantHepatotoxicity of diclofenacTransplant/deathDouble-blind trialPrescribed non-steroidal anti-inflammatory drugsProspective clinical trialsAdverse hepatic effectsALT/ASTRates of laboratoryAnti-inflammatory drugsProspective trialArthritis patientsLiver injuryRheumatoid arthritisClinical eventsHepatic diseaseCausality assessment
2004
The hepatotoxicity of non‐steroidal anti‐inflammatory drugs
Rubenstein JH, Laine L. The hepatotoxicity of non‐steroidal anti‐inflammatory drugs. Alimentary Pharmacology & Therapeutics 2004, 20: 373-380. PMID: 15298630, DOI: 10.1111/j.1365-2036.2004.02092.x.Peer-Reviewed Original ResearchConceptsNon-steroidal anti-inflammatory drug usersNon-steroidal anti-inflammatory drugsAnti-inflammatory drugsLiver injuryDrug usersParticular non-steroidal anti-inflammatory drugsComparative riskPopulation-based epidemiological studyRare complicationExcess riskRelevant hepatotoxicityInclusion criteriaMethodological qualityEpidemiological studiesPrecise riskPatient countsCumulative exposureInjuryHospitalizationDrugsRiskHepatotoxicityIncidenceCurrent useDeath