1998
Esophageal Disease in Patients with AIDS: Diagnosis and Treatment
Bonacini M, Laine L. Esophageal Disease in Patients with AIDS: Diagnosis and Treatment. Gastrointestinal Endoscopy Clinics Of North America 1998, 8: 811-823. PMID: 9730933, DOI: 10.1016/s1052-5157(18)30233-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEsophageal diseaseRetrosternal chest painChest painGastrointestinal complaintsEsophageal symptomsHIV infectionOpportunistic infectionsPoor outcomeShorter survivalNutritional intakeMean survivalPatientsSymptomsInfectionAIDSDiseaseDiagnosisSurvivalOdynophagiaDysphagiaImmunosuppressionPainComplaintsIntakeMonths
1994
The natural history of esophageal candidiasis after successful treatment in patients with AIDS
Laine L. The natural history of esophageal candidiasis after successful treatment in patients with AIDS. Gastroenterology 1994, 107: 744-746. PMID: 8076760, DOI: 10.1016/0016-5085(94)90122-8.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAntifungal AgentsCandidiasisEsophageal DiseasesFluconazoleFollow-Up StudiesHumansRecurrenceConceptsEsophageal candidiasisOral thrushImmunodeficiency syndromeAntifungal therapySuccessful treatmentNatural historyMonthly clinical assessmentsRecurrent esophageal candidiasisPosttreatment endoscopySymptomatic recurrenceEndoscopic resolutionEsophageal symptomsMost patientsOral therapyClinical resolutionRecurrent episodesEntry criteriaClinical assessmentBACKGROUND/Prior episodesPatientsCandidiasisSubsequent episodesTherapySubsequent course
1993
Protein-losing enteropathy and hypoalbuminemia in AIDS
Laine L, Garcia F, McGilligan K, Malinko A, Sinatra F, Thomas D. Protein-losing enteropathy and hypoalbuminemia in AIDS. AIDS 1993, 7: 837-840. PMID: 8363760, DOI: 10.1097/00002030-199306000-00012.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAIDS-Related Opportunistic InfectionsAlpha 1-AntitrypsinDiarrheaFecesFemaleHumansMaleProspective StudiesProtein-Losing EnteropathiesRegression AnalysisSarcoma, KaposiSerum AlbuminConceptsNormal bowel habitsProtein-losing enteropathyFecal alphaBowel habitsNormal serum albuminNormal albuminFecal alpha 1Normal albumin groupUrban county hospitalGroup of patientsDevelopment of hypoalbuminemiaUpper endoscopyFlexible sigmoidoscopyAlbumin groupMucosal diseaseCounty HospitalHypoalbuminemiaMAIN OUTCOMEProspective assessmentSerum albuminPatientsLinear regression analysisDiarrheaSignificant negative correlationGross abnormalities
1992
Fluconazole compared with ketoconazole for the treatment of Candida esophagitis in AIDS. A randomized trial.
Laine L, Dretler RH, Conteas CN, Tuazon C, Koster FM, Sattler F, Squires K, Islam MZ. Fluconazole compared with ketoconazole for the treatment of Candida esophagitis in AIDS. A randomized trial. Annals Of Internal Medicine 1992, 117: 655-60. PMID: 1308663, DOI: 10.7326/0003-4819-117-8-655.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultCandidiasisDouble-Blind MethodEsophagitisEsophagoscopyFemaleFluconazoleHumansKetoconazoleMaleConceptsCandida esophagitisCounty hospital settingFluconazole-treated patientsDouble-blind trialResolution of symptomsOral antifungal agentsEnd of therapyEndoscopic responseRetrosternal painStudy medicationClinical cureEsophageal symptomsSymptomatic improvementTreat analysisImmunodeficiency syndromeEndoscopic cureAntifungal therapyEsophageal brushingsHospital settingPatientsSide effectsWeek 1U.S. CentersEsophagitisTherapy
1988
A prospective trial of an anti-splatter device for the protection of endoscopic personnel from potentially AIDS-infective fluids
Laine L. A prospective trial of an anti-splatter device for the protection of endoscopic personnel from potentially AIDS-infective fluids. Gastrointestinal Endoscopy 1988, 34: 470-471. PMID: 3234685, DOI: 10.1016/s0016-5107(88)71438-8.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeBiopsyEndoscopesEquipment DesignGastrointestinal DiseasesHumansOccupational DiseasesPersonnel, HospitalProspective Studies
1987
Protein-Losing Enteropathy in Acquired Immunodeficiency Syndrome due to Intestinal Kaposi's Sarcoma
Laine L, Politoske EJ, Gill P. Protein-Losing Enteropathy in Acquired Immunodeficiency Syndrome due to Intestinal Kaposi's Sarcoma. JAMA Internal Medicine 1987, 147: 1174-1175. PMID: 3592885, DOI: 10.1001/archinte.1987.00370060170028.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultDuodenal NeoplasmsHumansJejunal NeoplasmsMaleNeoplasms, Multiple PrimaryProtein-Losing EnteropathiesSarcoma, KaposiSerum AlbuminConceptsProtein-losing enteropathyIntestinal Kaposi's sarcomaKaposi's sarcomaImmunodeficiency syndromeFecal alpha-1-antitrypsinAcquired Immunodeficiency SyndromeAlpha-1 antitrypsinAnkle edemaPleural effusionMarked elevationGastrointestinal tractSarcomaEnteropathyPatientsHypoalbuminemiaAIDSSyndromeEdemaEffusionTractAntitrypsinMonths