2022
Rebleeding in peptic ulcer bleeding – a nationwide cohort study of 19,537 patients
Laursen S, Stanley A, Laine L, de Muckadell O. Rebleeding in peptic ulcer bleeding – a nationwide cohort study of 19,537 patients. Scandinavian Journal Of Gastroenterology 2022, 57: 1423-1429. PMID: 35853234, DOI: 10.1080/00365521.2022.2098050.Peer-Reviewed Original ResearchConceptsPeptic ulcer bleedingNationwide cohort studyUlcer bleedingHemodynamic instabilityCohort studyDuodenal ulcerHigh-risk endoscopic stigmataNon-ulcer lesionsHigh-risk stigmataLogistic regression analysisEndoscopic stigmataPersistent bleedingEndoscopic therapyFrequent complicationConsecutive patientsSuch patientsPrognostic consequencesHigh riskPatientsInterventional radiologyBleedingTwo-fold increaseMortalityUlcersStrongest predictor
2021
Fresh frozen plasma transfusion in acute variceal haemorrhage: Results from a multicentre cohort study
Mohanty A, Kapuria D, Canakis A, Lin H, Amat MJ, Paniz G, Placone NT, Thomasson R, Roy H, Chak E, Baffy G, Curry MP, Laine L, Rustagi T. Fresh frozen plasma transfusion in acute variceal haemorrhage: Results from a multicentre cohort study. Liver International 2021, 41: 1901-1908. PMID: 33969607, DOI: 10.1111/liv.14936.Peer-Reviewed Original ResearchConceptsAcute variceal hemorrhageFresh frozen plasma transfusionFrozen plasma transfusionFFP transfusionLength of stayPlasma transfusionVariceal hemorrhageCohort studyClinical outcomesEnd-stage liver disease (MELD) scoreStage liver disease scoreTertiary health care centerSevere variceal bleedingLiver Disease scoreMulticentre cohort studyRetrospective cohort studyHigh-risk patientsOdds of mortalityPoor clinical outcomeHealth care centersMultivariable regression analysisEligible patientsActive bleedingVariceal bleedingMultivariable analysisNeural network predicts need for red blood cell transfusion for patients with acute gastrointestinal bleeding admitted to the intensive care unit
Shung D, Huang J, Castro E, Tay JK, Simonov M, Laine L, Batra R, Krishnaswamy S. Neural network predicts need for red blood cell transfusion for patients with acute gastrointestinal bleeding admitted to the intensive care unit. Scientific Reports 2021, 11: 8827. PMID: 33893364, PMCID: PMC8065139, DOI: 10.1038/s41598-021-88226-3.Peer-Reviewed Original ResearchConceptsAcute gastrointestinal bleedingRed blood cell transfusionBlood cell transfusionGastrointestinal bleedingHigh-risk patientsCell transfusionRed blood cellsPatient cohortIntensive Care III (MIMIC-III) critical care databaseIntensive care unit staySevere acute gastrointestinal bleedingPacked red blood cellsBlood cellsCommon gastrointestinal causesLaboratory test featuresTime-updated dataIntensive care unitValidation patient cohortCritical care databaseLarge urban hospitalMedical Information MartInternal validation setGastrointestinal causesUnit stayCare unit
2020
Use of Proton Pump Inhibitors Increases Risk of Incident Kidney Stones
Simonov M, Abel EA, Skanderson M, Masoud A, Hauser RG, Brandt CA, Wilson FP, Laine L. Use of Proton Pump Inhibitors Increases Risk of Incident Kidney Stones. Clinical Gastroenterology And Hepatology 2020, 19: 72-79.e21. PMID: 32147588, PMCID: PMC7483196, DOI: 10.1016/j.cgh.2020.02.053.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesFemaleHumansKidney CalculiMaleProton Pump InhibitorsRetrospective StudiesRisk FactorsConceptsProton pump inhibitorsPPI useKidney stonesCohort studyLevothyroxine useTime-varying Cox proportional hazardsHistamine-2 receptor antagonistsPropensity score-matched subsetIncident kidney stonesUrinary ion concentrationsLarge cohort studyCox proportional hazardsPropensity matching analysisDose-dependent increaseNegative control exposureH2RA usePPI usersMost patientsPPI usageAcid suppressionAdjusted analysisMedication usageRetrospective studyPump inhibitorsUnadjusted analyses
2019
The Shock Index is not accurate at predicting outcomes in patients with upper gastrointestinal bleeding
Saffouri E, Blackwell C, Laursen SB, Laine L, Dalton HR, Ngu J, Shultz M, Norton R, Stanley AJ. The Shock Index is not accurate at predicting outcomes in patients with upper gastrointestinal bleeding. Alimentary Pharmacology & Therapeutics 2019, 51: 253-260. PMID: 31642558, DOI: 10.1111/apt.15541.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overArea Under CurveBlood TransfusionCohort StudiesEndoscopy, GastrointestinalFemaleGastrointestinal HemorrhageHospitalizationHumansMaleMiddle AgedMortalityPredictive Value of TestsPrognosisProspective StudiesReproducibility of ResultsRisk AssessmentSeverity of Illness IndexShockSurvival AnalysisUpper Gastrointestinal TractYoung AdultConceptsUpper gastrointestinal bleedingGlasgow-Blatchford scoreShock indexGastrointestinal bleedingABC scoreMajor transfusionAcute upper gastrointestinal bleedingUK National Confidential EnquiryAdmission Rockall scoreSevere gastrointestinal bleedingMajor clinical endpointsPredictors of outcomeNational Confidential EnquiryRockall scoreBlatchford scoreEndoscopic therapyConsecutive patientsHospital admissionConfidential EnquiryProspective studyClinical endpointsPatient outcomesRisk scoreDeath reportsBleeding
2015
Can a Computerized Simulator Assess Skill Level and Improvement in Performance of ERCP?
Sahakian AB, Laine L, Jamidar PA, Siddiqui UD, Duffy A, Ciarleglio MM, Deng Y, Nagar A, Aslanian HR. Can a Computerized Simulator Assess Skill Level and Improvement in Performance of ERCP? Digestive Diseases And Sciences 2015, 61: 722-730. PMID: 26572779, DOI: 10.1007/s10620-015-3939-7.Peer-Reviewed Original ResearchConceptsTotal procedure timeProcedure timePrimary outcomeAcademic tertiary referral centerShorter total procedure timeTertiary referral centerPerformance of ERCPReferral centerCohort studyRetrograde cholangiographyERCP proceduresTrainee experienceGastroenterology fellowsSurgical skills centerFlexible endoscopyERCP trainingLittle dataGastroenterology facultyERCPSignificant differencesConsiderable riskSession 2Session 1Baseline sessionsOutcomes
2013
The Utility of Esophagogastroduodenoscopy Before Endoscopic Ultrasonography in Patients Undergoing Endoscopic Ultrasonography for Pancreatico-biliary and Mediastinal Indications
Sahakian AB, Aslanian HR, Mehra M, Rossi F, Laine L, Sanchez M, Ciarleglio MM, Adimoolam V, Siddiqui UD. The Utility of Esophagogastroduodenoscopy Before Endoscopic Ultrasonography in Patients Undergoing Endoscopic Ultrasonography for Pancreatico-biliary and Mediastinal Indications. Journal Of Clinical Gastroenterology 2013, 47: 857-860. PMID: 23632349, DOI: 10.1097/mcg.0b013e31828ba28c.Peer-Reviewed Original ResearchConceptsEndoscopic ultrasonographyMeaningful lesionsMedical managementEUS examinationMulticenter prospective cohort studyLarge community practiceUtility of esophagogastroduodenoscopyProportion of patientsProspective cohort studyTertiary referral centerLarge hiatal herniaCohort studyReferral centerHiatal herniaPrimary outcomeBarrett's esophagusProspective dataLuminal lesionsPractice patternsEsophagogastroduodenoscopyNeoplastic lesionsOblique-viewing echoendoscopesHyperplastic gastricPatientsCombined outcome
2009
How Common Is Diclofenac-Associated Liver Injury? Analysis of 17,289 Arthritis Patients in a Long-Term Prospective Clinical Trial
Laine L, Goldkind L, Curtis SP, Connors LG, Yanqiong Z, Cannon CP. How Common Is Diclofenac-Associated Liver Injury? Analysis of 17,289 Arthritis Patients in a Long-Term Prospective Clinical Trial. The American Journal Of Gastroenterology 2009, 104: ajg2008149. PMID: 19174782, DOI: 10.1038/ajg.2008.149.Peer-Reviewed Original ResearchConceptsLiver-related hospitalizationsNon-steroidal anti-inflammatory drugsMonths of therapyAminotransferase elevationLiver eventsClinical trialsLong-term prospective clinical trialsLarge double-blind trialDeath/transplantHepatotoxicity of diclofenacTransplant/deathDouble-blind trialPrescribed non-steroidal anti-inflammatory drugsProspective clinical trialsAdverse hepatic effectsALT/ASTRates of laboratoryAnti-inflammatory drugsProspective trialArthritis patientsLiver injuryRheumatoid arthritisClinical eventsHepatic diseaseCausality assessment
2004
Utilization of nonsteroidal anti-inflammatory drugs and antisecretory agents: a managed care claims analysis
Ofman JJ, Badamgarav E, Henning JM, Knight K, Laine L. Utilization of nonsteroidal anti-inflammatory drugs and antisecretory agents: a managed care claims analysis. The American Journal Of Medicine 2004, 116: 835-842. PMID: 15178499, DOI: 10.1016/j.amjmed.2004.02.028.Peer-Reviewed Original ResearchConceptsCOX-2 inhibitorsCardiac eventsHealth care costsGastrointestinal bleedingTraditional NSAIDsHigh riskGreater total health care costsNonsteroidal anti-inflammatory drug therapyCare costsAnti-inflammatory drug therapyCOX-2 inhibitor therapyTotal health care costsCyclooxygenase-2 selective inhibitorNonsteroidal anti-inflammatory drugsCardiac risk profileProton pump inhibitorsAnti-inflammatory drugsLogistic regression analysisNSAID therapyNSAID usersGastrointestinal riskInhibitor useNonselective NSAIDsInhibitor therapyCardiac risk
2003
Gastrointestinal health care resource utilization with chronic use of COX-2-specific inhibitors versus traditional NSAIDs1 1The Institute for Effectiveness Research, LLC, is a subsidiary of Medco Health Solutions, Inc., a Merck Company.
Laine L, Wogen J, Yu H. Gastrointestinal health care resource utilization with chronic use of COX-2-specific inhibitors versus traditional NSAIDs1 1The Institute for Effectiveness Research, LLC, is a subsidiary of Medco Health Solutions, Inc., a Merck Company. Gastroenterology 2003, 125: 389-395. PMID: 12891540, DOI: 10.1016/s0016-5085(03)00900-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnti-Inflammatory Agents, Non-SteroidalCohort StudiesCost-Benefit AnalysisCyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsFemaleGastrointestinal DiseasesHealth ResourcesHumansIsoenzymesLongitudinal StudiesMaleMembrane ProteinsMiddle AgedProstaglandin-Endoperoxide SynthasesRetrospective StudiesConceptsChronic NSAID therapyCoxib therapyNSAID therapyChronic nonsteroidal anti-inflammatory drug (NSAID) therapyNonsteroidal anti-inflammatory drug therapyAnti-inflammatory drug therapyHealth care resource utilizationCOX-2-specific inhibitorsU.S. administrative claims databaseMedco Health SolutionsProportion of patientsAdministrative claims databaseGastrointestinal eventsNewer coxibsInitial prescriptionChronic useClaims databaseDrug therapyClinical trialsDrug costsNew NSAIDClinical practicePatientsTherapyAbstractText