2023
Trends in Upper Gastrointestinal Bleeding in Patients on Primary Prevention Aspirin: A Nationwide Emergency Department Sample Analysis, 2016-2020
Li D, Laine L, Shung D. Trends in Upper Gastrointestinal Bleeding in Patients on Primary Prevention Aspirin: A Nationwide Emergency Department Sample Analysis, 2016-2020. The American Journal Of Medicine 2023, 136: 1179-1186.e1. PMID: 37696350, PMCID: PMC10841721, DOI: 10.1016/j.amjmed.2023.08.010.Peer-Reviewed Original ResearchConceptsUpper gastrointestinal bleedingGastrointestinal bleedingRed blood cell transfusionNationwide Emergency Department SamplePrimary cardiovascular preventionRecent guideline recommendationsBlood cell transfusionProportion of hospitalizationsEmergency Department SampleMedicare reimbursementInternational Statistical ClassificationRelated Health ProblemsCardiovascular preventionCell transfusionOlder patientsHospital admissionCommon etiologyGuideline recommendationsMajor complicationsUlcer diseaseEndoscopic interventionRevision codesAppropriate indicationsRecent guidelinesCardiovascular diseasePresentation of the Julius M. Friedenwald Medal to Sheila E. Crowe, MD
Laine L, Hecht G. Presentation of the Julius M. Friedenwald Medal to Sheila E. Crowe, MD. Gastroenterology 2023, 164: 1324-1328. PMID: 37061896, DOI: 10.1053/j.gastro.2023.03.212.Peer-Reviewed Original Research
2022
Trends in characteristics, management, and outcomes of patients presenting with gastrointestinal bleeding to emergency departments in the United States from 2006 to 2019
Zheng NS, Tsay C, Laine L, Shung DL. Trends in characteristics, management, and outcomes of patients presenting with gastrointestinal bleeding to emergency departments in the United States from 2006 to 2019. Alimentary Pharmacology & Therapeutics 2022, 56: 1543-1555. PMID: 36173090, PMCID: PMC9669230, DOI: 10.1111/apt.17238.Peer-Reviewed Original ResearchConceptsGastrointestinal bleedingLength of stayEmergency departmentMultivariable analysisIncidence of GIBRed blood cell transfusionNationwide Emergency Department SampleBlood cell transfusionIncidence of patientsOutcomes of patientsSex-adjusted incidenceEmergency Department SampleCase fatality rateRecent epidemiologic studiesProportion of casesED dischargeMore comorbiditiesCell transfusionRBC transfusionMore patientsComorbid populationEpidemiological evaluationInpatient costsPrimary diagnosisEpidemiologic studiesVonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the United States and Europe: Randomized Clinical Trial
Chey WD, Mégraud F, Laine L, López LJ, Hunt BJ, Howden CW. Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the United States and Europe: Randomized Clinical Trial. Gastroenterology 2022, 163: 608-619. PMID: 35679950, DOI: 10.1053/j.gastro.2022.05.055.Peer-Reviewed Original ResearchConceptsEradication rateHelicobacter pylori infectionTriple therapyDual therapyPylori infectionProton pump inhibitor-based triple therapyTreatment-emergent adverse eventsInhibitor-based triple therapyPotassium-competitive acid blockerEfficacy of vonoprazanH pylori eradicationPhase 3 trialOverall study populationAmoxicillin-resistant strainsClarithromycin-resistant strainsH pylori infectionTreatment-naïve adultsPylori eradicationAdverse eventsSecondary outcomesPrimary outcomeStandard treatmentClinical trialsStudy populationAcid blocker
2020
Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry
Kelly CR, Yen EF, Grinspan AM, Kahn SA, Atreja A, Lewis JD, Moore TA, Rubin DT, Kim AM, Serra S, Nersesova Y, Fredell L, Hunsicker D, McDonald D, Knight R, Allegretti JR, Pekow J, Absah I, Hsu R, Vincent J, Khanna S, Tangen L, Crawford CV, Mattar MC, Chen LA, Fischer M, Arsenescu RI, Feuerstadt P, Goldstein J, Kerman D, Ehrlich AC, Wu GD, Laine L. Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry. Gastroenterology 2020, 160: 183-192.e3. PMID: 33011173, PMCID: PMC8034505, DOI: 10.1053/j.gastro.2020.09.038.Peer-Reviewed Original ResearchConceptsClostridioides difficile infectionMicrobiota transplantationSafety profileNational registryProspective real-world studyFull safety profileProspective safety dataBaseline patient characteristicsInflammatory bowel diseaseIrritable bowel syndromeFecal microbiota transplantationLong-term safety outcomesGood safety profileReal-world studyAbdominal painBowel syndromePatient characteristicsReal-world practiceBowel diseaseCDI recurrenceDifficile infectionSafety dataSafety outcomesEffectiveness outcomesSevere symptomsMonitoring Fecal Microbiota Transplantation Practice in a Rapidly Evolving Health and Regulatory Environment
Kelly CR, Laine LA, Wu GD. Monitoring Fecal Microbiota Transplantation Practice in a Rapidly Evolving Health and Regulatory Environment. Gastroenterology 2020, 159: 2004-2006. PMID: 32841646, PMCID: PMC7443160, DOI: 10.1053/j.gastro.2020.08.039.Commentaries, Editorials and Letters
2019
Presentation of the Julius M. Friedenwald Medal to John I. Allen
Laine L, Ganz RA. Presentation of the Julius M. Friedenwald Medal to John I. Allen. Gastroenterology 2019, 156: 2330-2334. PMID: 31029707, DOI: 10.1053/j.gastro.2019.04.026.Commentaries, Editorials and Letters
2017
The AGA’s Fecal Microbiota Transplantation National Registry: An Important Step Toward Understanding Risks and Benefits of Microbiota Therapeutics
Kelly CR, Kim AM, Laine L, Wu GD. The AGA’s Fecal Microbiota Transplantation National Registry: An Important Step Toward Understanding Risks and Benefits of Microbiota Therapeutics. Gastroenterology 2017, 152: 681-684. PMID: 28143773, DOI: 10.1053/j.gastro.2017.01.028.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2016
Yield of repeat forward-view examination of the right side of the colon in screening and surveillance colonoscopy
Clark BT, Parikh ND, Laine L. Yield of repeat forward-view examination of the right side of the colon in screening and surveillance colonoscopy. Gastrointestinal Endoscopy 2016, 84: 126-132. PMID: 26769408, PMCID: PMC4912931, DOI: 10.1016/j.gie.2015.12.030.Peer-Reviewed Original ResearchConceptsAdenoma detection rateForward-view examinationOverall adenoma detection rateSecond examinationRight sideSurveillance colonoscopyAdditional adenomasWest Haven Veterans Affairs Medical CenterVeterans Affairs Medical CenterBoston Bowel Preparation Scale scoreDistal colon cancerNumber of patientsYears of ageDevelopment of cancerSecondary outcomesPrimary outcomeMen 50Prospective studySurveillance intervalsAdenoma detectionDetection rateMedical CenterInitial examinationPatientsColon cancer
2015
Factors impacting physicians’ decisions to prevent variceal hemorrhage
Yan K, Bridges J, Augustin S, Laine L, Garcia-Tsao G, Fraenkel L. Factors impacting physicians’ decisions to prevent variceal hemorrhage. BMC Gastroenterology 2015, 15: 55. PMID: 25934271, PMCID: PMC4423490, DOI: 10.1186/s12876-015-0287-1.Peer-Reviewed Original ResearchConceptsEndoscopic variceal ligationEradication of varicesLiver diseaseFirst variceal bleedMore daysSpecific treatment attributesLatent class analysisMechanism of actionVariceal bleedVariceal hemorrhageLarge varicesVariceal ligationPhysician characteristicsTreatment preferencesTreatment characteristicsTreatment attributesGroup 2Side effectsPrevention strategiesClass analysisVaricesPatientsPhysiciansDistinct subgroupsStandardized patients
2014
Variation in polyp size estimation among endoscopists and impact on surveillance intervals
Chaptini L, Chaaya A, Depalma F, Hunter K, Peikin S, Laine L. Variation in polyp size estimation among endoscopists and impact on surveillance intervals. Gastrointestinal Endoscopy 2014, 80: 652-659. PMID: 24679658, DOI: 10.1016/j.gie.2014.01.053.Peer-Reviewed Original ResearchCauses of Bleeding and Outcomes in Patients Hospitalized With Upper Gastrointestinal Bleeding
Kim JJ, Sheibani S, Park S, Buxbaum J, Laine L. Causes of Bleeding and Outcomes in Patients Hospitalized With Upper Gastrointestinal Bleeding. Journal Of Clinical Gastroenterology 2014, 48: 113-118. PMID: 23685847, DOI: 10.1097/mcg.0b013e318297fb40.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overEndoscopy, GastrointestinalEsophageal and Gastric VaricesEsophagitisFemaleGastrointestinal HemorrhageHematemesisHospital MortalityHospitalizationHumansLength of StayMaleMedicaidMedicareMelenaMiddle AgedPeptic UlcerPeptic Ulcer HemorrhageRetreatmentRetrospective StudiesUnited StatesConceptsUpper gastrointestinal bleedingGastrointestinal bleedingCommon causeOutcomes of UGIBVariceal upper gastrointestinal bleedingNonvariceal upper gastrointestinal bleedingCause of bleedingRisk of deathLower socioeconomic patientsUrban US hospitalsErosive esophagitisInpatient mortalityRepeat endoscopyUpper endoscopyConsecutive patientsClinical outcomesPeptic ulcerMean ageMedical CenterUrban hospitalPatientsUS hospitalsMultivariate analysisHematemesisEndoscopy
2012
Trends for Incidence of Hospitalization and Death Due to GI Complications in the United States From 2001 to 2009
Laine L, Yang H, Chang SC, Datto C. Trends for Incidence of Hospitalization and Death Due to GI Complications in the United States From 2001 to 2009. The American Journal Of Gastroenterology 2012, 107: 1190. PMID: 22688850, DOI: 10.1038/ajg.2012.168.Peer-Reviewed Original ResearchConceptsCase fatalityGI complicationsLGI bleedingUGI bleedingUGI complicationsGastrointestinal complicationsLower gastrointestinal complicationsColonic diverticular bleedingIncidence of hospitalizationNational inpatient databasePeptic ulcer bleedingPrimary discharge diagnosisSex-adjusted incidenceUpper gastrointestinal complicationsCase fatality rateDiverticular bleedingUGI perforationsGI bleedingUlcer bleedingDischarge diagnosisInpatient DatabaseBleedingComplicationsFatality rateHospitalization
2010
ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use
Documents A, Abraham N, Hlatky M, Antman E, Bhatt D, Bjorkman D, Clark C, Furberg C, Johnson D, Kahi C, Laine L, Mahaffey K, Quigley E, Scheiman J, Sperling L, Tomaselli G. ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use. Journal Of The American College Of Cardiology 2010, 56: 2051-2066. PMID: 21126648, DOI: 10.1016/j.jacc.2010.09.010.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2009
Prescription rates of protective co‐therapy for NSAID users at high GI risk and results of attempts to improve adherence to guidelines
LAINE L, CONNORS L, GRIFFIN MR, CURTIS SP, KAUR A, CANNON CP. Prescription rates of protective co‐therapy for NSAID users at high GI risk and results of attempts to improve adherence to guidelines. Alimentary Pharmacology & Therapeutics 2009, 30: 767-774. PMID: 19594486, DOI: 10.1111/j.1365-2036.2009.04090.x.Peer-Reviewed Original Research
2008
Systematic Review of the Predictors of Recurrent Hemorrhage After Endoscopic Hemostatic Therapy for Bleeding Peptic Ulcers
Elmunzer BJ, Young SD, Inadomi JM, Schoenfeld P, Laine L. Systematic Review of the Predictors of Recurrent Hemorrhage After Endoscopic Hemostatic Therapy for Bleeding Peptic Ulcers. The American Journal Of Gastroenterology 2008, 103: ajg2008521. PMID: 18684171, DOI: 10.1111/j.1572-0241.2008.02070.x.Peer-Reviewed Original ResearchMeSH KeywordsHemostasis, EndoscopicHumansIncidencePeptic Ulcer HemorrhagePrognosisRecurrenceUnited StatesConceptsEndoscopic therapyIndependent predictorsRecurrent hemorrhageProspective studySystematic reviewIntensive care unit observationLarge ulcer sizePosterior duodenal ulcerSecond-look endoscopyEndoscopic hemostatic therapySignificant independent predictorsPrespecified inclusion criteriaComorbid illnessesHemodynamic instabilityHemostatic therapyDuodenal ulcerEndoscopic predictorsPrimary outcomeUlcer sizeMultivariable analysisPooled ratePeptic ulcerClinical managementBibliographic database searchInclusion criteria
2006
A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience
Goldkind L, Laine L. A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience. Pharmacoepidemiology And Drug Safety 2006, 15: 213-220. PMID: 16456879, DOI: 10.1002/pds.1207.Peer-Reviewed Original ResearchMeSH KeywordsAdverse Drug Reaction Reporting SystemsAlanine TransaminaseAnti-Inflammatory Agents, Non-SteroidalArchivesBenzophenonesBiomarkersBromobenzenesChemical and Drug Induced Liver InjuryHumansLiverPhenylacetatesPropionatesRandomized Controlled Trials as TopicUnited StatesUnited States Food and Drug AdministrationConceptsAcute liver failureNonsteroidal anti-inflammatory drugsSerious hepatotoxicityLiver failureRisk of ALFSystematic reviewDifferent nonsteroidal anti-inflammatory drugsCommon adverse eventsHepatic enzyme elevationFlu-like symptomsDrug-induced hepatotoxicityAnti-inflammatory drugsClinical trial dataSymptomatic hepatitisALT elevationElevated transaminasesAdverse eventsEnzyme elevationDrug withdrawalHepatocellular jaundiceRare caseMedWatch systemDrug AdministrationHepatotoxicityTrial data
2004
Utilization of nonsteroidal anti-inflammatory drugs and antisecretory agents: a managed care claims analysis
Ofman JJ, Badamgarav E, Henning JM, Knight K, Laine L. Utilization of nonsteroidal anti-inflammatory drugs and antisecretory agents: a managed care claims analysis. The American Journal Of Medicine 2004, 116: 835-842. PMID: 15178499, DOI: 10.1016/j.amjmed.2004.02.028.Peer-Reviewed Original ResearchConceptsCOX-2 inhibitorsCardiac eventsHealth care costsGastrointestinal bleedingTraditional NSAIDsHigh riskGreater total health care costsNonsteroidal anti-inflammatory drug therapyCare costsAnti-inflammatory drug therapyCOX-2 inhibitor therapyTotal health care costsCyclooxygenase-2 selective inhibitorNonsteroidal anti-inflammatory drugsCardiac risk profileProton pump inhibitorsAnti-inflammatory drugsLogistic regression analysisNSAID therapyNSAID usersGastrointestinal riskInhibitor useNonselective NSAIDsInhibitor therapyCardiac risk
1998
Twice-daily, 10-day triple therapy with omeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in duodenal ulcer disease: results of three multicenter, double-blind, United States trials
Laine L, Suchower L, Frantz J, Connors A, Neil G. Twice-daily, 10-day triple therapy with omeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in duodenal ulcer disease: results of three multicenter, double-blind, United States trials. The American Journal Of Gastroenterology 1998, 93: ajg1998488. PMID: 9820381, DOI: 10.1111/j.1572-0241.1998.00602.x.Peer-Reviewed Original ResearchConceptsDuodenal ulcer diseaseTriple therapyEradication rateUlcer diseaseH. pylori-infected patientsDaily triple therapyDays of omeprazoleDuodenal ulcer historyProtocol cure ratesProtocol eradication ratesTreat eradication ratesHelicobacter pylori eradicationPylori-infected patientsOAC patientsStudy medicationTreat populationUlcer historyPylori eradicationStudy drugAdverse eventsTwice DailyControlled TrialsDuodenal ulcerCure ratePatients