Effects of Ioversol versus Iothalamate on Endothelin Release and Radiocontrast Nephropathy
HEYMAN S, CLARK B, CANTLEY L, SPOKES K, ROSEN S, BREZIS M, EPSTEIN F. Effects of Ioversol versus Iothalamate on Endothelin Release and Radiocontrast Nephropathy. Investigative Radiology 1993, 28: 313-318. PMID: 8478171, DOI: 10.1097/00004424-199304000-00011.Peer-Reviewed Original ResearchConceptsEffects of ioversolEndothelin releaseRadiocontrast nephropathyRadiocontrast agentsEqui-iodine dosesRelease of endothelinLow-osmolar agentsCultured bovine aortic endothelial cellsAortic endothelial cellsRenal vasoconstrictionBovine aortic endothelial cellsRenal vasoconstrictorCreatinine clearanceRenal functionOsmolar agentsRenal toxicityMorphologic damageNormal ratsVascular endotheliumSalt depletionNephropathyRenal medullaRatsEndothelial cellsIoversol