Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling*
Rameh L, Rhee S, Spokes K, Kazlauskas A, Cantley L, Cantley L. Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling*. Journal Of Biological Chemistry 1998, 273: 23750-23757. PMID: 9726983, DOI: 10.1074/jbc.273.37.23750.Peer-Reviewed Original ResearchMeSH KeywordsAndrostadienesBinding SitesCalciumChromonesEnzyme InhibitorsHumansIsoenzymesKineticsMorpholinesPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhospholipase C gammaPlatelet-Derived Growth FactorReceptors, Platelet-Derived Growth FactorRecombinant Fusion ProteinsSignal TransductionTransfectionTumor Cells, CulturedType C PhospholipasesWortmanninConceptsPlatelet-derived growth factor receptorIntracellular calcium releaseCalcium releasePI3KGrowth factor receptorIntracellular calciumIP3 generationInositol trisphosphate generationIP3 productionFactor receptorVivo relevanceCalcium signalingTrisphosphate generationHepG2 cellsSelective activationAddition of wortmanninPhospholipase Cγ