2014
Casein kinase 2 prevents mesenchymal transformation by maintaining Foxc2 in the cytoplasm
Golden D, Cantley LG. Casein kinase 2 prevents mesenchymal transformation by maintaining Foxc2 in the cytoplasm. Oncogene 2014, 34: 4702-4712. PMID: 25486430, PMCID: PMC4459945, DOI: 10.1038/onc.2014.395.Peer-Reviewed Original ResearchConceptsCK2β regulatory subunitSerine 124Epithelial-mesenchymal transitionRegulatory subunitNuclear localizationCytoplasmic localizationCasein kinase 2 phosphorylation sitesDevelopmental epithelial-mesenchymal transitionMesenchymal transformationCell migrationEpithelial cellsDe novo accumulationCK2 associatesTranscriptional regulatorsMalignant breast cancer cellsPhosphorylation sitesCK2β expressionKinase subunitMesenchymal genesBreast epithelial cellsProper targetingAmino terminusNormal breast epithelial cellsNormal epithelial cellsLeucine promotes
2011
Macrophages Promote Cyst Growth in Polycystic Kidney Disease
Karihaloo A, Koraishy F, Huen SC, Lee Y, Merrick D, Caplan MJ, Somlo S, Cantley LG. Macrophages Promote Cyst Growth in Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2011, 22: 1809-1814. PMID: 21921140, PMCID: PMC3187181, DOI: 10.1681/asn.2011010084.Peer-Reviewed Original ResearchConceptsPolycystic kidney diseaseCyst-lining cellsKidney diseaseCyst growthPkd1-deficient cellsContribution of inflammationMacrophage-depleted miceVehicle-treated controlsPostnatal day 10Renal functionInflammatory componentIschemic injuryOrthologous modelCre miceCystic areasLiposomal clodronateCyst progressionRenal parenchymaCystic indexTubular cellsDay 10Therapeutic potentialDay 24Macrophage migrationMacrophages
2001
Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud
Karihaloo A, Karumanchi S, Barasch J, Jha V, Nickel C, Yang J, Grisaru S, Bush K, Nigam S, Rosenblum N, Sukhatme V, Cantley L. Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 12509-12514. PMID: 11606725, PMCID: PMC60084, DOI: 10.1073/pnas.221205198.Peer-Reviewed Original Research
2000
Differential MAPK Pathways Utilized for HGF- and EGF-dependent Renal Epithelial Morphogenesis*
Karihaloo A, O'Rourke D, Nickel C, Spokes K, Cantley L. Differential MAPK Pathways Utilized for HGF- and EGF-dependent Renal Epithelial Morphogenesis*. Journal Of Biological Chemistry 2000, 276: 9166-9173. PMID: 11118451, DOI: 10.1074/jbc.m009963200.Peer-Reviewed Original ResearchConceptsHepatocyte growth factorP42/44 mitogen-activated protein kinase (MAPK) pathwayEGF-induced cell motilityProtein kinase kinase inhibitor PD98059Mitogen-activated protein kinase kinase inhibitor PD98059Mitogen-activated protein kinase pathwayEGF-dependent migrationProcess formationEGF-stimulated cellsRenal epithelial morphogenesisIndependent signaling pathwaysKinase inhibitor PD98059ERK1/ERK2Protein kinase pathwayEpidermal growth factor receptor ligandsCultured renal epithelial cellsLigand hepatocyte growth factorGrowth factor receptor ligandsCell morphogenesisEpithelial morphogenesisRenal epithelial cellsMKK1 inhibitorCell motilityKinase pathwayInhibitor PD98059
1999
Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells
O’Rourke D, Sakurai H, Spokes K, Kjelsberg C, Takahashi M, Nigam S, Cantley L. Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells. American Journal Of Physiology 1999, 276: f581-f588. PMID: 10198418, DOI: 10.1152/ajprenal.1999.276.4.f581.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell MovementCell SurvivalCollagenDogsDrosophila ProteinsEpithelial CellsGlial Cell Line-Derived Neurotrophic Factor ReceptorsHepatocyte Growth FactorKidneyKidney MedullaKidney Tubules, CollectingMicePhosphorylationProto-Oncogene ProteinsProto-Oncogene Proteins c-retReceptor Protein-Tyrosine KinasesConceptsGlial-derived neurotropic factorCell survivalEpidermal growth factorC-RetHepatocyte growth factorProtein tyrosine kinase receptorsEpithelial cell morphogenesisEarly branching morphogenesisTyrosine-phosphorylated receptorsUreteric bud developmentProcess formationSpiny cystsCell morphogenesisTyrosine kinase receptorsEpithelial morphogenesisGrowth factorBranching morphogenesisExamination of mRNAEGF receptorMorphogenesisStable expressionKinase receptorsBud developmentSerum-free conditionsEarly regulation
1997
The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C*
Derman M, Toker A, Hartwig J, Spokes K, Falck JR, Chen C, Cantley L, Cantley L. The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C*. Journal Of Biological Chemistry 1997, 272: 6465-6470. PMID: 9045671, DOI: 10.1074/jbc.272.10.6465.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAndrostadienesAnimalsCell MembraneCell MovementDown-RegulationEnzyme ActivationEnzyme InhibitorsMiceNaphthalenesPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphotransferases (Alcohol Group Acceptor)Platelet-Derived Growth FactorProtein Kinase CSignal TransductionWortmanninConceptsProtein kinase CCell motilityLipid productsKinase CPKC family membersNIH 3T3 cellsIndependent PKC isoformsMembrane rufflingActin reorganizationCellular motilityPKC isoformsPtdInsVivo rolePhosphoinositideMotilityFirst demonstrationRecent studiesFamily membersComplete inhibitionCellsRufflingPhosphatidylinositolPrevious observationsIsoformsTrisphosphate