2001
Cell Surface Glypicans Are Low-Affinity Endostatin Receptors
Karumanchi S, Jha V, Ramchandran R, Karihaloo A, Tsiokas L, Chan B, Dhanabal M, Hanai J, Venkataraman G, Shriver Z, Keiser N, Kalluri R, Zeng H, Mukhopadhyay D, Chen R, Lander A, Hagihara K, Yamaguchi Y, Sasisekharan R, Cantley L, Sukhatme V. Cell Surface Glypicans Are Low-Affinity Endostatin Receptors. Molecular Cell 2001, 7: 811-822. PMID: 11336704, DOI: 10.1016/s1097-2765(01)00225-8.Peer-Reviewed Original ResearchConceptsHeparan sulfate glycosaminoglycansPotent anti-angiogenic proteinCell surface proteoglycansBranching morphogenesisEndothelial cellsGenetic studiesGlypicansExpression cloningSurface proteoglycansAntisense experimentsCell surfaceAnti-angiogenic proteinEndothelial cell surfaceLow-affinity receptorsSulfate glycosaminoglycansEndostatin bindingCellsReceptorsMorphogenesisEndostatin activityCloningProteinEndostatinBindingProteoglycans
1997
The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C*
Derman M, Toker A, Hartwig J, Spokes K, Falck JR, Chen C, Cantley L, Cantley L. The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C*. Journal Of Biological Chemistry 1997, 272: 6465-6470. PMID: 9045671, DOI: 10.1074/jbc.272.10.6465.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAndrostadienesAnimalsCell MembraneCell MovementDown-RegulationEnzyme ActivationEnzyme InhibitorsMiceNaphthalenesPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphotransferases (Alcohol Group Acceptor)Platelet-Derived Growth FactorProtein Kinase CSignal TransductionWortmanninConceptsProtein kinase CCell motilityLipid productsKinase CPKC family membersNIH 3T3 cellsIndependent PKC isoformsMembrane rufflingActin reorganizationCellular motilityPKC isoformsPtdInsVivo rolePhosphoinositideMotilityFirst demonstrationRecent studiesFamily membersComplete inhibitionCellsRufflingPhosphatidylinositolPrevious observationsIsoformsTrisphosphate
1996
An 11-Amino Acid Sequence from c-met Initiates Epithelial Chemotaxis via Phosphatidylinositol 3-Kinase and Phospholipase C (∗)
Derman M, Chen J, Spokes K, Songyang Z, Cantley L. An 11-Amino Acid Sequence from c-met Initiates Epithelial Chemotaxis via Phosphatidylinositol 3-Kinase and Phospholipase C (∗). Journal Of Biological Chemistry 1996, 271: 4251-4255. PMID: 8626770, DOI: 10.1074/jbc.271.8.4251.Peer-Reviewed Original Research3T3 CellsAmino Acid SequenceAnimalsCell LineChemotaxisCloning, MolecularEpitheliumHepatocyte Growth FactorKidney TubulesMiceMolecular Sequence DataPeptide FragmentsPhosphatidylinositol 3-KinasesPhosphotransferases (Alcohol Group Acceptor)Platelet-Derived Growth FactorPoint MutationProto-Oncogene ProteinsProto-Oncogene Proteins c-metReceptor Protein-Tyrosine KinasesReceptors, Platelet-Derived Growth FactorRecombinant ProteinsTransfectionType C Phospholipases