2015
The Role of p204 in Kidney Injury
Marlier A, Huen S, Lengyel P, Cantley L. The Role of p204 in Kidney Injury. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.807.1.Peer-Reviewed Original ResearchAcute kidney injuryIschemia-reperfusion injuryRenal ischemia-reperfusion injuryChronic kidney diseaseKidney injuryPeak serum creatinine levelClassical inflammatory stimuliSerum creatinine levelsTubular cell necrosisCD45-positive cellsWhole-body knockoutAKI biomarkersCreatinine levelsKidney diseaseCHI3L1 expressionKidney ischemiaKidney fibrosisInflammasome activationInflammatory stimuliReparative phasePositive cellsTherapeutic targetBone marrowWT controlsCell necrosis
2011
Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair
Lee S, Huen S, Nishio H, Nishio S, Lee HK, Choi BS, Ruhrberg C, Cantley LG. Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair. Journal Of The American Society Of Nephrology 2011, 22: 317-326. PMID: 21289217, PMCID: PMC3029904, DOI: 10.1681/asn.2009060615.Peer-Reviewed Original ResearchConceptsTubular cell proliferationProinflammatory macrophagesM2 phenotypeKidney injuryKidney repairInterstitial inflammatory cell infiltrateIschemia/reperfusion injuryRenal tubular cell proliferationTubular cell necrosisInflammatory cell infiltrateMacrophage-depleted miceDepletion of macrophagesIschemia/reperfusionBone marrow-derived macrophagesCell proliferationRenal tubular cellsMarrow-derived macrophagesAppearance of macrophagesLater time pointsKidney reperfusionTubule injuryCell infiltrateReperfusion injuryKidney damageMacrophage depletion