Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction
Cantley L, Spokes K, Clark B, McMahon E, Carter J, Epstein F. Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction. Kidney International 1993, 44: 1217-1223. PMID: 8301922, DOI: 10.1038/ki.1993.371.Peer-Reviewed Original ResearchConceptsRenal blood flowRole of endothelinRenal artery constrictionEndothelin receptor antagonistsBlood flowRenal vasoconstrictionArtery constrictionReceptor antagonistSystemic blood pressureUrinary prostaglandin E2Absence of indomethacinRenal hypoperfusionBlood pressureRenal perfusionAortic ringsIntact ratsProstaglandin E2Sustained decreaseNormal ratsRadiocontrast agentsBaseline valuesProstaglandin synthesisProstaglandin formationRatsIndomethacin