1998
Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate*
Bae Y, Cantley L, Chen C, Kim S, Kwon K, Rhee S. Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate*. Journal Of Biological Chemistry 1998, 273: 4465-4469. PMID: 9468499, DOI: 10.1074/jbc.273.8.4465.Peer-Reviewed Original ResearchConceptsPLC-gamma isozymesPhospholipase CSrc homology 2 domainNIH 3T3 cellsCOS-7 cellsSpecific phospholipase CPLC gamma tyrosine phosphorylationAction of PISignal transductionCatalytic subunitTyrosine phosphorylationSpecific PIInhibitor LY294002PLC activationCell membranePhosphatidylinositolInositol phosphate formationIsozymesActivationCellsTransductionPIPhosphorylationSubunitsBisphosphate
1997
The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C*
Derman M, Toker A, Hartwig J, Spokes K, Falck JR, Chen C, Cantley L, Cantley L. The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C*. Journal Of Biological Chemistry 1997, 272: 6465-6470. PMID: 9045671, DOI: 10.1074/jbc.272.10.6465.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAndrostadienesAnimalsCell MembraneCell MovementDown-RegulationEnzyme ActivationEnzyme InhibitorsMiceNaphthalenesPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphotransferases (Alcohol Group Acceptor)Platelet-Derived Growth FactorProtein Kinase CSignal TransductionWortmanninConceptsProtein kinase CCell motilityLipid productsKinase CPKC family membersNIH 3T3 cellsIndependent PKC isoformsMembrane rufflingActin reorganizationCellular motilityPKC isoformsPtdInsVivo rolePhosphoinositideMotilityFirst demonstrationRecent studiesFamily membersComplete inhibitionCellsRufflingPhosphatidylinositolPrevious observationsIsoformsTrisphosphate