1995
Induction of heat-shock proteins does not prevent renal tubular injury following ischemia
Joannidis M, Cantley L, Spokes K, Medina R, Pullman J, Rosen S, Epstein F. Induction of heat-shock proteins does not prevent renal tubular injury following ischemia. Kidney International 1995, 47: 1752-1759. PMID: 7643546, DOI: 10.1038/ki.1995.242.Peer-Reviewed Original ResearchConceptsHeat shock proteinsMedullary hypoxic injuryPossible protective effectRenal tubular injuryDifferent experimental modelsSevere morphological damageSerum creatinineTubular injuryCross clampingIschemic injuryRight kidneyRenal arteryHypoxic injuryControl ratsIntact ratsRenal cortexProtective effectImmunohistochemical meansUrea nitrogenProximal tubulesHeat shockRenal cellsRat kidneyKidneyMorphological damage
1993
Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction
Cantley L, Spokes K, Clark B, McMahon E, Carter J, Epstein F. Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction. Kidney International 1993, 44: 1217-1223. PMID: 8301922, DOI: 10.1038/ki.1993.371.Peer-Reviewed Original ResearchConceptsRenal blood flowRole of endothelinRenal artery constrictionEndothelin receptor antagonistsBlood flowRenal vasoconstrictionArtery constrictionReceptor antagonistSystemic blood pressureUrinary prostaglandin E2Absence of indomethacinRenal hypoperfusionBlood pressureRenal perfusionAortic ringsIntact ratsProstaglandin E2Sustained decreaseNormal ratsRadiocontrast agentsBaseline valuesProstaglandin synthesisProstaglandin formationRatsIndomethacin