2020
Polycystin 2 is increased in disease to protect against stress-induced cell death
Brill AL, Fischer TT, Walters JM, Marlier A, Sewanan LR, Wilson PC, Johnson EK, Moeckel G, Cantley LG, Campbell SG, Nerbonne JM, Chung HJ, Robert ME, Ehrlich BE. Polycystin 2 is increased in disease to protect against stress-induced cell death. Scientific Reports 2020, 10: 386. PMID: 31941974, PMCID: PMC6962458, DOI: 10.1038/s41598-019-57286-x.Peer-Reviewed Original ResearchConceptsPolycystin-2General cellular homeostasisCell deathStress-induced cell deathPathological cell deathAutosomal dominant polycystic kidney diseaseEndoplasmic reticulum membraneCellular homeostasisCellular stressPrimary ciliaUbiquitous expressionExpression changesCell stressReticulum membraneTransient receptor potential cation channelHuman diseasesMultiple tissuesEndogenous roleDominant polycystic kidney diseaseTissue typesCation channelsPolycystic kidney diseaseDifferent pathological statesMultiple diseasesKidney disease
2004
Microarray analysis of in vitro pericyte differentiation reveals an angiogenic program of gene expression
Kale S, Hanai J, Chan B, Karihaloo A, Grotendorst G, Cantley L, Sukhatme VP. Microarray analysis of in vitro pericyte differentiation reveals an angiogenic program of gene expression. The FASEB Journal 2004, 19: 1-30. PMID: 15579670, DOI: 10.1096/fj.04-1604fje.Peer-Reviewed Original ResearchConceptsPericytes/vascular smooth muscle cellsVascular smooth muscle cellsHuman umbilical vein ECsGene expressionMicroarray analysisPericyte differentiationNormal blood vessel developmentAngiogenic programGene expression changesBlood vessel developmentEndothelial cellsEPH receptor A2Human umbilical vein endothelial cellsCoculture systemUmbilical vein endothelial cellsExpression changesCell differentiationVascular developmentVein endothelial cellsVessel developmentGenesMature vasculatureFunctional significanceHB-EGFIntegrin alpha5