2021
Fetal programming of polycystic ovary syndrome: Effects of androgen exposure on prenatal ovarian development
Barsky M, Merkison J, Hosseinzadeh P, Yang L, Bruno-Gaston J, Dunn J, Gibbons W, Blesson C. Fetal programming of polycystic ovary syndrome: Effects of androgen exposure on prenatal ovarian development. The Journal Of Steroid Biochemistry And Molecular Biology 2021, 207: 105830. PMID: 33515680, PMCID: PMC8056856, DOI: 10.1016/j.jsbmb.2021.105830.Peer-Reviewed Original ResearchConceptsGene expressionPolycystic ovary syndromeOvarian developmentDifferential gene expressionFetal gonadal developmentDownregulated genesTranscriptional pathwaysCandidate genesMitochondrial studiesMitochondrial oxygen consumptionProton leakOvary syndromeGonadal developmentMitochondrial functionFetal programmingMitochondrial ultrastructureStrong hereditary componentMitochondrial dysfunctionMitochondrial efficiencyMitochondriaAndrogen exposureGenesInheritance patternOocyte maturationAndrogen programming
2020
Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls
Chappell N, Barsky M, Shah J, Peavey M, Yang L, Sangi-Haghpeykar H, Gibbons W, Blesson C. Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls. F&S Reports 2020, 1: 125-132. PMID: 34223228, PMCID: PMC8244380, DOI: 10.1016/j.xfre.2020.05.006.Peer-Reviewed Original ResearchPolycystic ovary syndromeHyperandrogenic polycystic ovary syndromeHigher miscarriage rateMiscarriage rateBody mass index-matched patientsPolycystic ovary syndrome patientsAcademic fertility clinicRetrospective cohort analysisTertiary hospital settingObstetric outcomesRotterdam criteriaControl patientsOvary syndromeAltered fertilitySyndrome patientsCohort analysisHospital settingBlastulation ratePatientsOvarian folliclesFertility clinicsEmbryo morphokineticsEarly embryo developmentWomenFertilization rate