Featured Publications
Machine learning in time-lapse imaging to differentiate embryos from young vs old mice
Yang L, Leynes C, Pawelka A, Lorenzo I, Chou A, Lee B, Heaney J. Machine learning in time-lapse imaging to differentiate embryos from young vs old mice. Biology Of Reproduction 2024, 110: 1115-1124. PMID: 38685607, PMCID: PMC11180621, DOI: 10.1093/biolre/ioae056.Peer-Reviewed Original ResearchMaternal agePreimplantation genetic testingMorphokinetic parameters of embryosEarly embryo developmentMaternal miceNo significant differenceEmbryo transferTime-lapse microscopyGenetic testingAge-related phenotypesHuman embryosYoung donorsSignificant differenceNon-invasive approachEmbryo developmentCleavage stagesYounger counterpartsMiceNon-invasive technologyEmbryosAged embryosPhenotypeAgeTime-lapse imagingMorphokinetics
2020
Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls
Chappell N, Barsky M, Shah J, Peavey M, Yang L, Sangi-Haghpeykar H, Gibbons W, Blesson C. Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls. F&S Reports 2020, 1: 125-132. PMID: 34223228, PMCID: PMC8244380, DOI: 10.1016/j.xfre.2020.05.006.Peer-Reviewed Original ResearchPolycystic ovary syndromeHyperandrogenic polycystic ovary syndromeHigher miscarriage rateMiscarriage rateBody mass index-matched patientsPolycystic ovary syndrome patientsAcademic fertility clinicRetrospective cohort analysisTertiary hospital settingObstetric outcomesRotterdam criteriaControl patientsOvary syndromeAltered fertilitySyndrome patientsCohort analysisHospital settingBlastulation ratePatientsOvarian folliclesFertility clinicsEmbryo morphokineticsEarly embryo developmentWomenFertilization rate