2016
Daily Relations Among Affect, Urge, Targeted Naltrexone, and Alcohol Use in Young Adults
Bold KW, Fucito LM, Corbin WR, DeMartini KS, Leeman RF, Kranzler HR, O’Malley S. Daily Relations Among Affect, Urge, Targeted Naltrexone, and Alcohol Use in Young Adults. Experimental And Clinical Psychopharmacology 2016, 24: 367-375. PMID: 27690505, PMCID: PMC5111359, DOI: 10.1037/pha0000090.Peer-Reviewed Original ResearchConceptsYoung adultsDouble-blind clinical trialHeavy drinkingSerious public health problemDose of medicationPublic health problemAlcohol-related interventionsTargeted naltrexoneNaltrexone groupOpioid antagonistRisk factorsClinical trialsFamily historyNaltrexone effectsGreater oddsAlcohol consumptionHealth problemsAlcohol dependenceSecondary analysisPlaceboNaltrexoneNaltrexone's abilityAdultsMedicationsDrinking
2015
How Imaging Glutamate, γ‐Aminobutyric Acid, and Dopamine Can Inform the Clinical Treatment of Alcohol Dependence and Withdrawal
Hillmer AT, Mason GF, Fucito LM, O'Malley SS, Cosgrove KP. How Imaging Glutamate, γ‐Aminobutyric Acid, and Dopamine Can Inform the Clinical Treatment of Alcohol Dependence and Withdrawal. Alcohol Clinical And Experimental Research 2015, 39: 2268-2282. PMID: 26510169, PMCID: PMC4712074, DOI: 10.1111/acer.12893.Peer-Reviewed Original ResearchConceptsAlcohol dependenceΓ-aminobutyric acidClinical treatmentMajor public health issuePublic health issuePositron emission tomographyRelapse prevention strategiesSingle photon emissionSpecific imaging modalityAlcohol withdrawalTobacco smokingGABA systemNeurotransmitter systemsNeurochemical basisPrevention strategiesDopaminergic functioningEmission tomographyHealth issuesImaging modalitiesWithdrawalSex differencesImaging literatureDopamineTomographyGlutamate
2012
Cigarette Smoking Predicts Differential Benefit from Naltrexone for Alcohol Dependence
Fucito LM, Park A, Gulliver SB, Mattson ME, Gueorguieva RV, O'Malley SS. Cigarette Smoking Predicts Differential Benefit from Naltrexone for Alcohol Dependence. Biological Psychiatry 2012, 72: 832-838. PMID: 22541040, PMCID: PMC3410039, DOI: 10.1016/j.biopsych.2012.03.023.Peer-Reviewed Original ResearchConceptsCigarette smokingAlcohol dependenceBehavioral interventionsAlcohol-dependent smokersCombination of medicationsBaseline demographic differencesPoor treatment outcomesPoor treatment responseDrinking outcomesBetter drinking outcomesSevere alcohol dependenceAlcohol-dependent individualsCigarette intakeAlcohol use outcomesMedical managementPharmacological treatmentTreatment outcomesTreatment responseSmokingSmokersCOMBINE StudyAlcoholism typologyDrinking-related variablesTreatment assignmentNonsmokers
2011
A preliminary investigation of varenicline for heavy drinking smokers
Fucito LM, Toll BA, Wu R, Romano DM, Tek E, O’Malley S. A preliminary investigation of varenicline for heavy drinking smokers. Psychopharmacology 2011, 215: 655-663. PMID: 21221531, PMCID: PMC3645986, DOI: 10.1007/s00213-010-2160-9.Peer-Reviewed Original ResearchConceptsHeavy drinking smokersActive medicationPretreatment groupAlcohol cravingHeavy drinkersOpen-label phaseSmoking cessation pharmacotherapyEffects of vareniclineHeavy drinking daysGreater reductionPlacebo leadVarenicline pretreatmentCessation counselingCessation pharmacotherapyAbstinence ratesCigarette smokingVareniclineSmoking changesDrinking daysPotential treatmentSmokingAlcohol dependenceEntire study periodSmokersHeavy drinking
2009
The familial aggregation of cannabis use disorders
Merikangas KR, Li JJ, Stipelman B, Yu K, Fucito L, Swendsen J, Zhang H. The familial aggregation of cannabis use disorders. Addiction 2009, 104: 622-629. PMID: 19335660, PMCID: PMC2794246, DOI: 10.1111/j.1360-0443.2008.02468.x.Peer-Reviewed Original ResearchConceptsSpouses of probandsFirst-degree relativesCannabis use disorderLife-time historyUse disordersAnxiety disordersAlcohol abuse/dependenceFamilial aggregationAbuse/dependenceFirst-degree adult relativesComorbid moodElevated riskFamily-based approachPsychiatric clinicAffective disordersAlcohol dependencePsychiatric conditionsFamily study methodDrug abuseFamilial factorsDisordersAdult relativesCannabisFamilial transmissionGenetic factors