2019
Mendelian randomization provides support for obesity as a risk factor for meningioma
Takahashi H, Cornish AJ, Sud A, Law PJ, Disney-Hogg L, Calvocoressi L, Lu L, Hansen HM, Smirnov I, Walsh KM, Schramm J, Hoffmann P, Nöthen MM, Jöckel KH, Schildkraut JM, Simon M, Bondy M, Wrensch M, Wiemels JL, Claus EB, Turnbull C, Houlston RS. Mendelian randomization provides support for obesity as a risk factor for meningioma. Scientific Reports 2019, 9: 309. PMID: 30670737, PMCID: PMC6343031, DOI: 10.1038/s41598-018-36186-6.Peer-Reviewed Original ResearchConceptsRisk of meningiomaMeningioma riskObesity-related traitsLipoprotein cholesterolBlood pressureRisk factorsOdds ratioLow-density lipoprotein cholesterolHigh-density lipoprotein cholesterolMendelian randomizationCause of meningiomaGenetic instrumentsDiastolic blood pressureEpidemiological observational studiesSystolic blood pressureBody mass indexBody fat percentageWaist circumferenceTotal cholesterolMass indexObservational studyMeningioma patientsMeningiomasBasal metabolic rateObesity
2018
Genome-wide association analysis identifies a meningioma risk locus at 11p15.5
Claus EB, Cornish AJ, Broderick P, Schildkraut JM, Dobbins SE, Holroyd A, Calvocoressi L, Lu L, Hansen HM, Smirnov I, Walsh KM, Schramm J, Hoffmann P, Nöthen MM, Jöckel KH, Swerdlow A, Larsen SB, Johansen C, Simon M, Bondy M, Wrensch M, Houlston RS, Wiemels JL. Genome-wide association analysis identifies a meningioma risk locus at 11p15.5. Neuro-Oncology 2018, 20: 1485-1493. PMID: 29762745, PMCID: PMC6176799, DOI: 10.1093/neuonc/noy077.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorCase-Control StudiesChromosomes, Human, Pair 11FemaleFollow-Up StudiesGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansLinkage DisequilibriumMaleMeningeal NeoplasmsMeningiomaMiddle AgedPolymorphism, Single NucleotidePrognosisRisk FactorsYoung AdultConceptsGenome-wide association studiesRisk lociGenome-wide association analysisSusceptibility lociNeural crest-derived structuresSignificant heritable basisNumber of genesIndependent sample seriesNew susceptibility lociHeritable basisGenetic basisGenome ProjectAssociation studiesAssociation analysisLinkage disequilibriumLociMeningioma developmentReference panelPolygenic modelCentral roleUK10K dataAdult brain tumorsRIC8AMeningeal coveringsGenes
2012
Cigarette Smoking and Risk of Meningioma: The Effect of Gender
Claus EB, Walsh KM, Calvocoressi L, Bondy ML, Schildkraut JM, Wrensch M, Wiemels JL. Cigarette Smoking and Risk of Meningioma: The Effect of Gender. Cancer Epidemiology Biomarkers & Prevention 2012, 21: 943-950. PMID: 22473761, PMCID: PMC3613227, DOI: 10.1158/1055-9965.epi-11-1059.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCase-Control StudiesFemaleHumansMaleMeningeal NeoplasmsMeningiomaMiddle AgedRisk FactorsSex FactorsSmokingConceptsCigarette smokingIntracranial meningiomasCase-control studyRisk of meningiomaDuration of useEffect of genderPast smokersMenopausal statusHormonal etiologyFemale casesMale casesMeningioma riskReduced riskElevated riskMeningioma casesSmokingCase statusGreater riskSimilar findingsMeningiomasRiskAdditional investigationNumber of studiesInconsistent findingsWomenDental x‐rays and risk of meningioma
Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Dental x‐rays and risk of meningioma. Cancer 2012, 118: 4530-4537. PMID: 22492363, PMCID: PMC3396782, DOI: 10.1002/cncr.26625.Peer-Reviewed Original ResearchConceptsRisk of meningiomaDental X-raysModifiable risk factorsIntracranial meningiomasRisk factorsAge 20Population-based case-control studyMain outcome measuresPrimary brain tumorsCase-control studyGreater frequencyPanorex filmsTumor locationBitewing examinationOutcome measuresElevated riskBrain tumorsControl groupMeningiomasYounger ageRadiation exposureAge 10AgePatientsRiskPostmenopausal hormone therapy and ductal carcinoma in situ: A population-based case–control study
Calvocoressi L, Stowe MH, Carter D, Claus EB. Postmenopausal hormone therapy and ductal carcinoma in situ: A population-based case–control study. Cancer Epidemiology 2012, 36: 161-168. PMID: 22317899, PMCID: PMC3613248, DOI: 10.1016/j.canep.2012.01.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBreast NeoplasmsCarcinoma in SituCarcinoma, Ductal, BreastCase-Control StudiesEstrogen Replacement TherapyFemaleHumansMiddle AgedOdds RatioConceptsPopulation-based case-control studyCase-control studyHormone therapySitu breast cancerBreast cancerDuctal carcinomaRisk of DCISPostmenopausal hormone therapyFrequency-matched controlsInvasive breast cancerPost-menopausal womenDuration of usePostmenopausal womenIncident casesBreast carcinomaDCISLarger studyCarcinomaCancerImportant covariatesEstrogenTherapyAge intervalsWomenCurrent use
2011
Family and personal medical history and risk of meningioma.
Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Family and personal medical history and risk of meningioma. Journal Of Neurosurgery 2011, 115: 1072-7. PMID: 21780859, PMCID: PMC3241000, DOI: 10.3171/2011.6.jns11129.Peer-Reviewed Original ResearchConceptsFirst-degree family historyPersonal medical historyMedical historyFamily historyMeningioma riskEpidemiology of meningiomaPrimary brain tumorsCase-control studyRisk of meningiomaUterine fibroid tumorsImmune conditionsThyroid cancerYoungest caseBreast cancerRole of hormonesBrain tumorsFibroid tumorsImmune systemControl individualsPatientsMeningiomasInfluence of geneticsStrong associationFurther studiesTumorsReduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls
Wiemels JL, Wrensch M, Sison JD, Zhou M, Bondy M, Calvocoressi L, Black PM, Yu H, Schildkraut JM, Claus EB. Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls. International Journal Of Cancer 2011, 129: 1932-1939. PMID: 21520030, PMCID: PMC3337969, DOI: 10.1002/ijc.25858.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesFemaleHumansHypersensitivityImmunoglobulin EMaleMeningeal NeoplasmsMeningiomaMiddle AgedConceptsAtopic allergyLower total serum IgEPhysician-diagnosed allergyRole of allergyTotal serum IgEHistory of allergyCentral nervous systemRandom digit dialingSerum IgESerum levelsFrequent tumorsRisk factorsIntracranial meningiomasAllergyImmune processesNervous systemMeningiomasStudy participantsNatural historyConsortium studyInverse relationshipFurther researchParticipantsIgEGeographic areas