2022
Pleiotropic MLLT10 variation confers risk of meningioma and estrogen-mediated cancers
Walsh KM, Zhang C, Calvocoressi L, Hansen HM, Berchuck A, Schildkraut JM, Bondy ML, Wrensch M, Wiemels JL, Claus EB. Pleiotropic MLLT10 variation confers risk of meningioma and estrogen-mediated cancers. Neuro-Oncology Advances 2022, 4: vdac044. PMID: 35702670, PMCID: PMC9187056, DOI: 10.1093/noajnl/vdac044.Peer-Reviewed Original ResearchRisk of meningiomaOvarian cancerBreast cancerER- breast cancerEstrogen receptor statusBody mass indexFemale breast cancerRisk of tumorsReceptor statusMass indexEstrogenic mechanismsHormonal factorsGenome-wide association studiesMeningiomasNormal meningesCancerMinor alleleCase-control datasetUK BiobankExpression quantitative trait lociMeningesRiskTumorsBreastAdiposity traits
2019
MNGI-12. PLEIOTROPIC MLLT10 VARIATION CONFERS RISK OF MENINGIOMA, BREAST, AND OVARIAN CANCERS
Walsh K, Zhang C, Calvocoressi L, Hansen H, Berchuck A, Schildkraut J, Bondy M, Wiemels J, Claus E. MNGI-12. PLEIOTROPIC MLLT10 VARIATION CONFERS RISK OF MENINGIOMA, BREAST, AND OVARIAN CANCERS. Neuro-Oncology 2019, 21: vi142-vi142. PMCID: PMC6847155, DOI: 10.1093/neuonc/noz175.594.Peer-Reviewed Original ResearchBody mass indexER- breast cancerRisk of meningiomaOvarian cancerBreast cancerMeningioma riskCancer riskElevated body mass indexHigher body fat percentageRisk allelesExogenous hormone useEstrogen receptor statusFemale breast cancerBreast cancer riskOvarian cancer riskBody fat percentageEndogenous hormonal factorsRecent genome-wide association studiesReceptor statusWaist circumferenceHormone useMass indexEpidemiologic studiesEstrogenic mechanismsHigh risk