Featured Publications
Evaluation of Complementary and Integrative Health Approaches Among US Veterans with Musculoskeletal Pain Using Propensity Score Methods
Han L, Goulet JL, Skanderson M, Bathulapalli H, Luther SL, Kerns RD, Brandt CA. Evaluation of Complementary and Integrative Health Approaches Among US Veterans with Musculoskeletal Pain Using Propensity Score Methods. Pain Medicine 2018, 20: 90-102. PMID: 29584926, PMCID: PMC6329442, DOI: 10.1093/pm/pny027.Peer-Reviewed Original ResearchConceptsIntegrative health approachesPS matchingCIH exposureMusculoskeletal painPropensity score methodsSelf-rated pain intensityHealth approachHigher pain intensity ratingsPain intensity outcomesChronic musculoskeletal painPain intensity ratingsIPTW modelsRetrospective cohortPain intensityChronic painClinical visitsInitial diagnosisChiropractic careUS veteransBaseline differencesTreatment weightingExposure groupPainScore methodTreatment effectivenessCognitive Aging Trajectories and Burdens of Disability, Hospitalization and Nursing Home Admission Among Community-living Older Persons
Han L, Gill TM, Jones BL, Allore HG. Cognitive Aging Trajectories and Burdens of Disability, Hospitalization and Nursing Home Admission Among Community-living Older Persons. The Journals Of Gerontology Series A 2015, 71: 766-771. PMID: 26511011, PMCID: PMC4888384, DOI: 10.1093/gerona/glv159.Peer-Reviewed Original ResearchConceptsNursing home admissionBurden of disabilityCommunity-living older personsHome admissionOlder personsGreater burdenCognitive trajectoriesMini-Mental State ExaminationCommunity-living personsCognitive aging trajectoriesNursing home placementPrecipitating Events ProjectLow incidence rateEquation Poisson modelsRapid cognitive declineBaseline cognitive functionAging trajectoriesGroup-based trajectory modelsThird of participantsADL disabilityHigher baseline cognitive functionInstrumental ADLIncidence rateDaily livingHospitalizationOpioid dosing trends over eight years among US Veterans with musculoskeletal disorders after returning from service in support of recent conflicts
Han L, Allore H, Goulet J, Bathulapali H, Skanderson M, Brandt C, Haskell S, Krebs E. Opioid dosing trends over eight years among US Veterans with musculoskeletal disorders after returning from service in support of recent conflicts. Annals Of Epidemiology 2017, 27: 563-569.e3. PMID: 28890282, PMCID: PMC5647654, DOI: 10.1016/j.annepidem.2017.08.015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalgesics, OpioidChronic PainDrug PrescriptionsElectronic PrescribingFemaleHumansMaleMental HealthMiddle AgedMusculoskeletal DiseasesOpioid-Related DisordersPrescription DrugsStress Disorders, Post-TraumaticUnited StatesUnited States Department of Veterans AffairsVeteransVeterans HealthYoung AdultConceptsHigh-dose prescribingOpioid prescriptionsMental health diagnosesMusculoskeletal disordersDaily morphine equivalentsHealth diagnosisHigh-dose therapyLong-term opioidsHigh-dose prescriptionsAverage daily dosePosttraumatic stress disorderMorphine equivalentsDose therapyDaily dosePatient characteristicsChronic painUS veteransOdds ratioPrescribingStress disorderBaseline periodGeographic confoundingVeteransPrescriptionOpioids
2024
Leveraging Electronic Health Records to Assess Residential Mobility Among Veterans in the Veterans Health Administration
Wang K, Hendrickson Z, Miller M, Abel E, Skanderson M, Erdos J, Womack J, Brandt C, Desai M, Han L. Leveraging Electronic Health Records to Assess Residential Mobility Among Veterans in the Veterans Health Administration. Medical Care 2024, 62: 458-463. PMID: 38848139, DOI: 10.1097/mlr.0000000000002017.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationElectronic health recordsResidential addressesHealth recordsHealth AdministrationLeveraging electronic health recordsInfluence health care utilizationVeterans Health Administration dataAssociations of sociodemographicsHealth care utilizationHealth care systemPatient's residential addressCross-sectional analysisGeneralized logistic regressionCare utilizationHealth systemResidential mobilitySubstance use disordersCare systemPatient's residenceLogistic regressionVeteransMultinomial outcomesHealthOdds
2022
Military sexual trauma and incident hypertension: a 16-year cohort study of young and middle-aged men and women
Gaffey AE, Rosman L, Sico JJ, Haskell SG, Brandt CA, Bathulapalli H, Han L, Dziura J, Skanderson M, Burg MM. Military sexual trauma and incident hypertension: a 16-year cohort study of young and middle-aged men and women. Journal Of Hypertension 2022, 40: 2307-2315. PMID: 35983872, DOI: 10.1097/hjh.0000000000003267.Peer-Reviewed Original ResearchConceptsIncident hypertensionRisk factorsPsychiatric disordersMultivariate Cox proportional hazards modelVeterans Health Administration dataGreater riskCox proportional hazards modelTrauma-related psychiatric disordersMiddle-aged veteransCardiovascular risk factorsBaseline blood pressureElevated cardiovascular riskLarge prospective cohortHealth Administration dataMiddle-aged menProportional hazards modelSex-specific analysesPosttraumatic stress disorderMilitary sexual traumaCardiovascular riskCohort studyProspective cohortBlood pressureTreatment attenuatesCardiovascular impactMultimorbidity measures differentially predicted mortality among older Chinese adults
Yao SS, Xu HW, Han L, Wang K, Cao GY, Li N, Luo Y, Chen YM, Su HX, Chen ZS, Huang ZT, Hu YH, Xu B. Multimorbidity measures differentially predicted mortality among older Chinese adults. Journal Of Clinical Epidemiology 2022, 146: 97-105. PMID: 35259446, DOI: 10.1016/j.jclinepi.2022.03.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedChinaChronic DiseaseHealth StatusHumansLongitudinal StudiesMiddle AgedMultimorbidityConceptsNet reclassification indexIntegrated discrimination improvementMultimorbidity measuresMortality prediction modelOlder Chinese adultsMultimorbidity patternsC-statisticCondition countMortality predictionChinese adultsMultimorbidity trajectoriesNet reclassification improvementCox regressionReclassification improvementReclassification indexChronic conditionsDiscrimination improvementMortality riskHigh riskIntegrated discriminationMultimorbidityStudy designMortalityAdultsAgePatterns of cardiometabolic multimorbidity and the risk of depressive symptoms in a longitudinal cohort of middle-aged and older Chinese
Huang ZT, Luo Y, Han L, Wang K, Yao SS, Su HX, Chen S, Cao GY, De Fries CM, Chen ZS, Xu HW, Hu YH, Xu B. Patterns of cardiometabolic multimorbidity and the risk of depressive symptoms in a longitudinal cohort of middle-aged and older Chinese. Journal Of Affective Disorders 2022, 301: 1-7. PMID: 34999125, DOI: 10.1016/j.jad.2022.01.030.Peer-Reviewed Original ResearchConceptsCardiometabolic multimorbidityCardiometabolic diseasesHeart diseaseDepressive symptomsSelf-reported chronic conditionsEpidemiological Studies Depression ScaleAbsence of strokeRisk of depressionRetirement Longitudinal Study 2011Multiple cardiometabolic diseasesDose effectMental health preventionOlder ChineseAdditive effectChronic conditionsDisease combinationsLongitudinal cohortDepression ScaleHigh riskMultimorbidityPerson-centered healthcareDiabetesSymptomsHealth preventionChina Health
2021
Functional Disability Among Older Versus Younger Adults With Advanced Non–Small-Cell Lung Cancer
Presley CJ, Arrato NA, Janse S, Shields PG, Carbone DP, Wong ML, Han L, Gill TM, Allore HG, Andersen BL. Functional Disability Among Older Versus Younger Adults With Advanced Non–Small-Cell Lung Cancer. JCO Oncology Practice 2021, 17: e848-e858. PMID: 33939536, PMCID: PMC8258136, DOI: 10.1200/op.20.01004.Peer-Reviewed Original ResearchConceptsBaseline disabilityFunctional disabilityAdvanced NSCLCBrain metastasesLung cancerHigher oddsUsual activitiesDepressive symptomsEastern Cooperative Oncology Group performance statusAdvanced non-small cell lung cancerNon-small cell lung cancerDisability groupsECOG PS 0Poor ECOG PSCell lung cancerFunctional status scoresECOG PSPatient characteristicsPerformance statusProspective cohortPS 0Systemic treatmentEuroQol-5DPsychologic symptomsDisease characteristics
2020
Cognitive frailty in relation to adverse health outcomes independent of multimorbidity: results from the China health and retirement longitudinal study
Chen C, Park J, Wu C, Xue Q, Agogo G, Han L, Hoogendijk EO, Liu Z, Wu Z. Cognitive frailty in relation to adverse health outcomes independent of multimorbidity: results from the China health and retirement longitudinal study. Aging 2020, 12: 23129-23145. PMID: 33221750, PMCID: PMC7746379, DOI: 10.18632/aging.104078.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAge FactorsAgedAged, 80 and overChinaCognitionCognitive AgingCognitive DysfunctionDisability EvaluationFemaleFrail ElderlyFrailtyFunctional StatusHealth SurveysHospitalizationHumansLongitudinal StudiesMaleMiddle AgedMobility LimitationMultimorbidityPrognosisRetirementRisk AssessmentRisk FactorsConceptsCognitive frailtyInstrumental ADLPhysical frailtyHealth outcomesCognitive impairmentAdverse health outcomesRetirement Longitudinal StudyPhysical frailty assessmentChinese older adultsFrailty assessmentIADL disabilitySecondary preventionDaily livingHigh riskMobility disabilityMultimorbidityFrailtyChina HealthNormal cognitionBaseline cognitionHealthy agingOlder adultsDeathBasic activitiesHospitalizationVision impairment, vision correction, and cognitive decline among middle-aged and older Chinese: results from the China health and retirement longitudinal study
Cao GY, Yao SS, Wang K, Han L, Chen ZS, Huang ZT, Zhang Q, Wang C, Hu YH, Xu B. Vision impairment, vision correction, and cognitive decline among middle-aged and older Chinese: results from the China health and retirement longitudinal study. Aging & Mental Health 2020, 25: 2028-2035. PMID: 33063527, DOI: 10.1080/13607863.2020.1828271.Peer-Reviewed Original ResearchAssociations between Multimorbidity and Physical Performance in Older Chinese Adults
Yao SS, Meng X, Cao GY, Huang ZT, Chen ZS, Han L, Wang K, Su HX, Luo Y, Hu Y, Xu B. Associations between Multimorbidity and Physical Performance in Older Chinese Adults. International Journal Of Environmental Research And Public Health 2020, 17: 4546. PMID: 32599778, PMCID: PMC7344642, DOI: 10.3390/ijerph17124546.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsiaChronic DiseaseFemaleHumansMiddle AgedMultimorbidityPhysical Functional PerformanceWalking SpeedConceptsSlow gait speedMultimorbidity patternsGait speedGrip strengthOlder Chinese adultsPhysical performanceHighest quartileChronic conditionsLowest quartileChinese adultsWorse physical performanceMaximum grip strengthRetirement Longitudinal Study 2011Average gait speedHealth care servicesMultimorbid populationClinical guidelinesOdds ratioMultimorbidityClinical settingChina HealthQuartileOlder adultsClinical performanceIncreased numberMultimorbidity among Two Million Adults in China
Wang X, Yao S, Wang M, Cao G, Chen Z, Huang Z, Wu Y, Han L, Xu B, Hu Y. Multimorbidity among Two Million Adults in China. International Journal Of Environmental Research And Public Health 2020, 17: 3395. PMID: 32414117, PMCID: PMC7277827, DOI: 10.3390/ijerph17103395.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseCerebrovascular diseaseMultimorbidity patternsMultimorbidity prevalenceBeijing Medical Claim DataMedical claims dataMiddle-aged groupOlder Chinese individualsMillion adultsMorbidity treatmentOlder patientsRheumatoid arthritisPreventive careHeart diseaseChronic diseasesClaims dataHypertensionOlder groupOlder adultsStrong associationDiseaseCOPDMultimorbidityChinese individualsAppropriate guidelinesAssociations Between Somatic Multimorbidity Patterns and Depression in a Longitudinal Cohort of Middle-Aged and Older Chinese
Yao SS, Cao GY, Han L, Huang ZT, Chen ZS, Su HX, Hu Y, Xu B. Associations Between Somatic Multimorbidity Patterns and Depression in a Longitudinal Cohort of Middle-Aged and Older Chinese. Journal Of The American Medical Directors Association 2020, 21: 1282-1287.e2. PMID: 31928934, DOI: 10.1016/j.jamda.2019.11.028.Peer-Reviewed Original ResearchMeSH KeywordsAgedChinaChronic DiseaseDepressionFemaleHumansLongitudinal StudiesMaleMiddle AgedMultimorbidityRisk FactorsConceptsChronic somatic conditionsSomatic multimorbidityDepressive symptomsOlder Chinese adultsSomatic conditionsChinese adultsEpidemiological Studies Depression ScaleLongitudinal associationsRetirement Longitudinal Study 2011Multimorbidity patternsLongitudinal cohortDepression ScaleRespiratory conditionsHigh riskGreater oddsRespiratory patternMental disordersSymptomsChina HealthGreater riskOlder populationOlder adultsSkeletal patternClinical practitionersDepression
2019
Associations between home deaths and end-of-life nursing care trajectories for community-dwelling people: a population-based registry study
Kjellstadli C, Han L, Allore H, Flo E, Husebo BS, Hunskaar S. Associations between home deaths and end-of-life nursing care trajectories for community-dwelling people: a population-based registry study. BMC Health Services Research 2019, 19: 698. PMID: 31615500, PMCID: PMC6794846, DOI: 10.1186/s12913-019-4536-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolContinuity of Patient CareFemaleHome Care ServicesHome NursingHospice CareHospitalsHumansIndependent LivingInfantInfant, NewbornLogistic ModelsLongitudinal StudiesMaleMiddle AgedNorwayNursing CarePalliative CareRegistriesResearch DesignRetrospective StudiesSkilled Nursing FacilitiesTerminal CareYoung AdultConceptsSkilled nursing facilitiesHome deathCommunity-dwelling peoplePlace of deathHome nursingSNF stayAssociation of placeNursing servicesPopulation-based registry studyHome nursing servicesPalliative home careContinuity of careRetrospective longitudinal studyDays of lifeMunicipal healthcare servicesLogistic regression modelsGroup-based trajectory modelsDeath RegistryMultinomial logistic regression modelsNorwegian CauseRegistry studyBackgroundFew studiesNational registryCare trajectoriesNursing hoursPrevalence and Patterns of Multimorbidity in a Nationally Representative Sample of Older Chinese: Results From the China Health and Retirement Longitudinal Study
Yao SS, Cao GY, Han L, Chen ZS, Huang ZT, Gong P, Hu Y, Xu B. Prevalence and Patterns of Multimorbidity in a Nationally Representative Sample of Older Chinese: Results From the China Health and Retirement Longitudinal Study. The Journals Of Gerontology Series A 2019, 75: 1974-1980. PMID: 31406983, DOI: 10.1093/gerona/glz185.Peer-Reviewed Original ResearchConceptsPatterns of multimorbidityPrevalence of multimorbidityMultimorbidity patternsRetirement Longitudinal StudyOlder ChineseChina HealthPopulation-based studyDemographic characteristicsIndividual chronic diseasesLongitudinal studyCommon multimorbidity patternsLogistic regression modelsParticipants' demographic characteristicsNationally Representative SampleEntire cohortPotential confoundersChronic diseasesRepresentative sampleMultimorbidityAlcohol consumptionMemory-related diseasesUrban-rural differencesPrevalenceInterventional implicationsResidential region
2018
Association between death and loss of stage N2 sleep features among critically Ill patients with delirium
Knauert MP, Gilmore EJ, Murphy TE, Yaggi HK, Van Ness PH, Han L, Hirsch LJ, Pisani MA. Association between death and loss of stage N2 sleep features among critically Ill patients with delirium. Journal Of Critical Care 2018, 48: 124-129. PMID: 30179762, PMCID: PMC6226351, DOI: 10.1016/j.jcrc.2018.08.028.Peer-Reviewed Original ResearchConceptsICU patientsIll patientsOdds ratioHigher oddsSleep spindlesIntensive care unit outcomesGrade of encephalopathySignificant sleep disruptionWorse ICU outcomeMedical ICU patientsAcute brain injuryObservational cohort studySedative-hypnotic useImportant prognostic valueLength of stayStage N2 sleepK-complexesCohort studyCritical illnessHospital dischargeRankin ScaleICU outcomesPrognostic valueSevere gradesMedical records
2013
Cardiovascular Disease and Hip Fracture among Older Inpatients in Beijing, China
Xu B, Han L, Liu H, Wang J, Bao XY, Xi HX, Zhao L, Yu GP. Cardiovascular Disease and Hip Fracture among Older Inpatients in Beijing, China. BioMed Research International 2013, 2013: 493696. PMID: 23936809, PMCID: PMC3713359, DOI: 10.1155/2013/493696.Peer-Reviewed Original ResearchConceptsHip fractureICD-10 codesCardiovascular diseaseHypertensive diseaseOlder inpatientsCerebrovascular diseaseHospitalization summary reportsOverall cardiovascular diseaseHip fracture patientsDiagnosis of CVDOccurrence rateChinese inpatientsFracture patientsCohort studyTertiary hospitalInpatientsDiseaseAssociationFracturesEuropean populationsComorbiditiesPatientsHospitalYearsDiagnosis
2006
Triggered sampling could help improve longitudinal studies of persons with elevated mortality risk
Dubin JA, Han L, Fried TR. Triggered sampling could help improve longitudinal studies of persons with elevated mortality risk. Journal Of Clinical Epidemiology 2006, 60: 288-293. PMID: 17292023, DOI: 10.1016/j.jclinepi.2006.06.012.Peer-Reviewed Original ResearchConceptsElevated mortality riskMortality riskChronic obstructive pulmonary diseaseLongitudinal studyCongestive heart failureObstructive pulmonary diseaseMixed effects modelsLongitudinal observational studyLongitudinal clinical studyStudy design featuresEffects modelHeart failurePulmonary diseaseAdvanced illnessTreatment preferencesClinical studiesObservational studyFirst triggerStudy designPatientsRiskValuable additionMean preferenceSimilar resultsIllness
2002
Symptoms of Delirium Among Elderly Medical Inpatients With or Without Dementia
Cole MG, McCusker J, Dendukuri N, Han L. Symptoms of Delirium Among Elderly Medical Inpatients With or Without Dementia. Journal Of Neuropsychiatry 2002, 14: 167-175. PMID: 11983791, DOI: 10.1176/jnp.14.2.167.Peer-Reviewed Original Research