2009
Emotional arousal in cocaine exposed toddlers: Prediction of behavior problems
Chaplin TM, Fahy T, Sinha R, Mayes LC. Emotional arousal in cocaine exposed toddlers: Prediction of behavior problems. Neurotoxicology And Teratology 2009, 31: 275-282. PMID: 19465113, PMCID: PMC2743887, DOI: 10.1016/j.ntt.2009.05.002.Peer-Reviewed Original ResearchConceptsEmotional arousalPrenatal cocaine exposureBehavior problemsAge 2 1/2 yearsCocaine exposureAge 5 1/2 yearsAge 2 1/2Subsequent behavior problemsLater psychopathologyEmotional responsesChild behaviorRegulation behaviorsArousalFrustrating taskToddlersTaskYear oldsMore referencesBoysEmotionsComplex relationsPsychopathologyBehaviorYouthFindings
2005
Event-related potentials in cocaine-exposed children during a Stroop task
Mayes LC, Molfese DL, Key AP, Hunter NC. Event-related potentials in cocaine-exposed children during a Stroop task. Neurotoxicology And Teratology 2005, 27: 797-813. PMID: 16111858, DOI: 10.1016/j.ntt.2005.05.011.Peer-Reviewed Original ResearchConceptsStroop paradigmCortical functioningEvent-related potentialsCocaine-exposed childrenEarly cocaine exposureCognitive processingStroop taskCE childrenExecutive functionERP methodologyDevelopmental courseCognitive functionTask processingFrontal maturationPotential studiesCocaine exposureInitial positive peakRegion involvementPositive peakChildrenFunctioningCocaine effectsCortical involvementParadigmMore time
2004
Impaired performance of children exposed in utero to cocaine on a novel test of visuospatial working memory
Schroder MD, Snyder PJ, Sielski I, Mayes L. Impaired performance of children exposed in utero to cocaine on a novel test of visuospatial working memory. Brain And Cognition 2004, 55: 409-412. PMID: 15177825, DOI: 10.1016/j.bandc.2004.02.062.Peer-Reviewed Original ResearchConceptsMaze Learning TestCocaine-exposed groupLearning TestRecall trialsGroton Maze Learning TestVisuospatial working memoryVisuospatial memory functionShort-term memoryInternal spatial mapPrenatal cocaine exposureChase testSignificant group differencesWorking memoryNeuropsychological measuresVisuospatial informationProcedural learningVisuomotor speedLearning trialsImpaired performanceMore errorsMemory functionGroup differencesCocaine exposureMin delayPossible impairment
2001
Perceptions and Attitudes Toward Prenatal Cocaine Exposure in Young Children
Leckman E, Mayes L, Hodgins H. Perceptions and Attitudes Toward Prenatal Cocaine Exposure in Young Children. Child Psychiatry & Human Development 2001, 31: 313-328. PMID: 11227990, DOI: 10.1023/a:1010286406789.Peer-Reviewed Original Research
1999
Developing brain and in utero cocaine exposure: Effects on neural ontogeny
MAYES L. Developing brain and in utero cocaine exposure: Effects on neural ontogeny. Development And Psychopathology 1999, 11: 685-714. PMID: 10624721, DOI: 10.1017/s0954579499002278.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureCocaine exposureNeural ontogenyNervous system ontogenyUtero cocaine exposureCNS ontogenyType of exposureMonoaminergic systemsMonoamine systemsPreclinical studiesCocaine effectsNeuropsychological effectsNervous systemPatterns of arousalPrimary siteNeural migrationCell proliferationYoung childrenTrophic roleCocaine-related effectsExposureBrainAttention regulationCandidate mechanismArousal
1998
Incidence of Passive Exposure to Crack/Cocaine and Clinical Findings in Infants Seen in an Outpatient Service
Lustbader A, Mayes L, McGee B, Jatlow P, Roberts W. Incidence of Passive Exposure to Crack/Cocaine and Clinical Findings in Infants Seen in an Outpatient Service. Pediatrics 1998, 102: e5-e5. PMID: 9651457, DOI: 10.1542/peds.102.1.e5.Peer-Reviewed Original ResearchMeSH KeywordsCocaineConnecticutCrack CocaineEnvironmental MonitoringEnzyme Multiplied Immunoassay TechniqueEpidemiological MonitoringFemaleGas Chromatography-Mass SpectrometryHumansIncidenceInfantInfant, NewbornNarcoticsOutpatient Clinics, HospitalPregnancyPrenatal Exposure Delayed EffectsProspective StudiesRadioimmunoassayRespiratory Tract InfectionsRetrospective StudiesSubstance Abuse DetectionConceptsYears of ageCocaine exposureRespiratory symptomsIll infantsMedical carePassive exposureYale-New Haven HospitalMaternal drug historyRIA-positive samplesEnzyme-multiplied immunoassay techniqueLower respiratory symptomsUrine toxicology resultsUpper respiratory symptomsRoutine clinical indicationsCurrent National InstituteInner-city populationPositive urine resultsHealth care resourcesSamples of urineChart reviewClinical findingsClinical symptomsMedical visitsEmergency departmentBirth weightRegulation of arousal and attention in preschool children exposed to cocaine prenatally.
Mayes L, Grillon C, Granger R, Schottenfeld R. Regulation of arousal and attention in preschool children exposed to cocaine prenatally. Annals Of The New York Academy Of Sciences 1998, 846: 126-43. PMID: 9668402.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureArousal regulationRegulation of arousalCocaine exposureAged childrenCocaine-exposed childrenFace of noveltyOngoing information processingSubstance-abusing familiesAttention regulationCocaine-exposed infantsEmotional reactivityImpaired attentionStructured tasksNeurobehavioral findingsStressful situationsInformation processingHuman infantsNeurophysiological findingsPreschool childrenArousalSuch childrenStartle responseStress circuitsNeurobehavioral effectsRegulation of Arousal and Attention in Preschool Children Exposed to Cocaine Prenatally
Mayes L, Grillon C, Granger R, Schottenfeld R. Regulation of Arousal and Attention in Preschool Children Exposed to Cocaine Prenatally. Annals Of The New York Academy Of Sciences 1998, 846: 126-143. PMID: 29087549, DOI: 10.1111/j.1749-6632.1998.tb09731.x.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureArousal regulationRegulation of arousalCocaine exposureAged childrenCocaine-exposed childrenFace of noveltyOngoing information processingSubstance-abusing familiesAttention regulationCocaine-exposed infantsEmotional reactivityImpaired attentionStructured tasksNeurobehavioral findingsStressful situationsInformation processingHuman infantsNeurophysiological findingsPreschool childrenArousalSuch childrenStartle responseStress circuitsNeurobehavioral effects
1996
Cocaine-abusing Parturients Undergoing Cesarean Section
Kain Z, Mayes L, Ferris C, Pakes J, Schottenfeld R. Cocaine-abusing Parturients Undergoing Cesarean Section. Anesthesiology 1996, 85: 1028-1035. PMID: 8916819, DOI: 10.1097/00000542-199611000-00010.Peer-Reviewed Original ResearchConceptsCocaine-abusing parturientsCesarean section deliverySection deliveryCesarean sectionCocaine useOperative blood lossDiastolic blood pressureDiastolic hypertensionPeripartum eventsAbruptio placentaeMaternal morbidityObstetric outcomesCohort studyFetal distressBlood lossBlood pressureIndependent predictorsVentricular dysrhythmiasAnesthetic implicationsEpidural anesthesiaIschemic episodesPregnant womenPrenatal careUnivariate analysisParturientsNeonatal Withdrawal Syndrome in Infants Exposed to Cocaine and Methadone
Mayes L, Carroll K. Neonatal Withdrawal Syndrome in Infants Exposed to Cocaine and Methadone. Substance Use & Misuse 1996, 31: 241-253. PMID: 8834011, DOI: 10.3109/10826089609045811.Peer-Reviewed Original ResearchConceptsNeonatal withdrawal syndromeWithdrawal syndromeIntrauterine growth retardationPositive urine screenMethadone maintenance programMore medicationsMethadone usePerinatal complicationsRespiratory distressUrine screensWithdrawal scoresConcomitant cocaineTerms of dosageWithdrawal managementGrowth retardationInfantsCocaineRegular useMethadoneSyndromeMothersMedicationsPrematurityComplicationsPregnancyExposure to cocaine: behavioral outcomes in preschool and school-age children.
Mayes L. Exposure to cocaine: behavioral outcomes in preschool and school-age children. NIDA Research Monograph 1996, 164: 211-29. PMID: 8809873.Peer-Reviewed Original ResearchThe conflicts for parenting drug dependent women--what does research show us?
Finnegan L, Kaltenbach K, Kandall S, Lester B, Mayes L, Paltrow L. The conflicts for parenting drug dependent women--what does research show us? NIDA Research Monograph 1996, 162: 67-9. PMID: 9066817.Peer-Reviewed Original Research
1995
Thrombocytopenia in pregnant women who use cocaine
Kain Z, Mayes L, Pakes J, Rosenbaum S, Schottenfeld R. Thrombocytopenia in pregnant women who use cocaine. American Journal Of Obstetrics And Gynecology 1995, 173: 885-890. PMID: 7573263, DOI: 10.1016/0002-9378(95)90360-7.Peer-Reviewed Original ResearchConceptsLow platelet countDrug-free groupPlatelet countCocaine groupHuman immunodeficiency virus statusCocaine-abusing parturientsRate of thrombocytopeniaIndependent risk factorAssociation of thrombocytopeniaCocaine-using groupIllicit drug useParturient populationSeropositive womenCohort studyPregnant womenDrug groupsPrenatal centersMedical recordsRisk factorsVirus statusMedical conditionsThrombocytopeniaIllicit drug usageNineteen subjectsOpiate group
1993
Neurobehavioral profiles of neonates exposed to cocaine prenatally.
Mayes L, Granger R, Frank M, Schottenfeld R, Bornstein M. Neurobehavioral profiles of neonates exposed to cocaine prenatally. Pediatrics 1993, 91: 778-83. PMID: 8464666, DOI: 10.1542/peds.91.4.778.Peer-Reviewed Original ResearchConceptsNeonatal Behavioral Assessment ScaleCocaine-exposed newbornsBirth weightMaternal cocaine useBehavioral Assessment ScaleSimilar sociodemographic characteristicsPostnatal complicationsHabituation performanceGestational ageCocaine exposureNBAS clustersNeurobehavioral assessmentNewbornsCocaine useSociodemographic characteristicsAssessment ScaleNeurobehavioral profileSignificant reductionSelective effectFirst yearDepressed performanceComplicationsNeonatesWeightCocaine