2024
Insights From Omics in Lyme Disease
Bockenstedt L, Belperron A. Insights From Omics in Lyme Disease. The Journal Of Infectious Diseases 2024, 230: s18-s26. PMID: 39140719, DOI: 10.1093/infdis/jiae250.Peer-Reviewed Original Research
2009
Langerhans Cell Deficiency Impairs Ixodes scapularis Suppression of Th1 Responses in Mice
Vesely DL, Fish D, Shlomchik MJ, Kaplan DH, Bockenstedt LK. Langerhans Cell Deficiency Impairs Ixodes scapularis Suppression of Th1 Responses in Mice. Infection And Immunity 2009, 77: 1881-1887. PMID: 19273564, PMCID: PMC2681756, DOI: 10.1128/iai.00030-09.Peer-Reviewed Original ResearchConceptsTh1 responseTick salivaLangerhans cell subsetsLC-deficient miceSkin dendritic cellsTh1 immune responseTh cell polarizationTh cell responsesRegional lymph nodesT cell responsesTick feedingSecondary lymphoid organsGamma interferon productionSpleens of miceWild-type miceIxodes scapularis ticksT helperDendritic cellsLymph nodesLN cellsCell subsetsImmunomodulatory effectsLymphoid organsTh2 cellsImmune response
2001
Natural Antibody Affects Survival of the SpirocheteBorrelia burgdorferi within Feeding Ticks
Belperron A, Bockenstedt L. Natural Antibody Affects Survival of the SpirocheteBorrelia burgdorferi within Feeding Ticks. Infection And Immunity 2001, 69: 6456-6462. PMID: 11553590, PMCID: PMC98781, DOI: 10.1128/iai.69.10.6456-6462.2001.Peer-Reviewed Original ResearchConceptsB cell-deficient miceNatural antibodiesControl miceConfocal immunofluorescence microscopySalivary glandsEarly host defenseBlood-sucking vectorsMammalian hostsFeeding ticksB. burgdorferi organismsNormal mouse serumTick midgutAbsence of exposureOuter surface protein AArthropod vectorsImmunofluorescence microscopyMammalian seraSurface protein ASpirochete Borrelia burgdorferiPolyclonal immunoglobulin MPathogen transmissionSpirochete burdenPassive transferBlood mealImmunoglobulin M
1999
Quantitative detection of Borrelia burgdorferi with a microtiter-based competitive polymerase chain reaction assay
Germer J, Ryckmann B, Moro M, Hofmeister E, Barthold S, Bockenstedt L, Persing D. Quantitative detection of Borrelia burgdorferi with a microtiter-based competitive polymerase chain reaction assay. Molecular Diagnosis 1999, 4: 185-193. PMID: 10553019, DOI: 10.1016/s1084-8592(99)80022-8.Peer-Reviewed Original ResearchConceptsLyme disease pathogenesisPolymerase chain reactionDisease pathogenesisBALB/c miceAvailable enzyme-linked immunosorbentB. burgdorferi flagellin geneChain reactionQuantitative competitive polymerase chain reactionEnzyme-linked immunosorbentCompetitive polymerase chain reactionImmunologic componentsInfectious burdenC miceInflammatory processC3H miceMurine modelAnimal modelsTissue weightTissue burdenLyme diseaseTarget tissuesSpecific target tissuesBorrelia burgdorferiDetection kitCompetitive internal standard