2011
The impact of nanoparticle ligand density on dendritic-cell targeted vaccines
Bandyopadhyay A, Fine RL, Demento S, Bockenstedt LK, Fahmy TM. The impact of nanoparticle ligand density on dendritic-cell targeted vaccines. Biomaterials 2011, 32: 3094-3105. PMID: 21262534, PMCID: PMC4570971, DOI: 10.1016/j.biomaterials.2010.12.054.Peer-Reviewed Original ResearchConceptsIL-10 responsesDEC-205 receptorIL-10Cytokine responsesT cellsSubsequent T cell responsesBlockade of CD36T cell responsesAntigen delivery systemDifferential cytokine responsesScavenger receptor CD36Vaccine delivery systemDC expressionVaccine efficacyDC functionDC productionReceptor CD36Cell responsesDelivery systemOVA nanoparticlesDelivery of therapeuticsCD36AntigenReceptorsSimilar pattern
2009
The Caspase 1 Inflammasome Is Not Required for Control of Murine Lyme Borreliosis
Liu N, Belperron AA, Booth CJ, Bockenstedt LK. The Caspase 1 Inflammasome Is Not Required for Control of Murine Lyme Borreliosis. Infection And Immunity 2009, 77: 3320-3327. PMID: 19487481, PMCID: PMC2715671, DOI: 10.1128/iai.00100-09.Peer-Reviewed Original ResearchConceptsCaspase-1 inflammasomeCaspase-1Immune responseHost defenseLyme borreliosisToll-like receptor-mediated responsesDay 14 postinfectionPrevalence of arthritisT cell responsesApoptosis-associated speck-like proteinMild transient elevationBorrelia burgdorferiMurine Lyme borreliosisReceptor-mediated responsesCaspase-1 deficiencyC-terminal caspase recruitment domainSpeck-like proteinAbility of macrophagesEnzyme caspase-1IL-18Humoral immunityInterleukin-1betaTransient elevationPathogen burdenInflammasomeLangerhans Cell Deficiency Impairs Ixodes scapularis Suppression of Th1 Responses in Mice
Vesely DL, Fish D, Shlomchik MJ, Kaplan DH, Bockenstedt LK. Langerhans Cell Deficiency Impairs Ixodes scapularis Suppression of Th1 Responses in Mice. Infection And Immunity 2009, 77: 1881-1887. PMID: 19273564, PMCID: PMC2681756, DOI: 10.1128/iai.00030-09.Peer-Reviewed Original ResearchConceptsTh1 responseTick salivaLangerhans cell subsetsLC-deficient miceSkin dendritic cellsTh1 immune responseTh cell polarizationTh cell responsesRegional lymph nodesT cell responsesTick feedingSecondary lymphoid organsGamma interferon productionSpleens of miceWild-type miceIxodes scapularis ticksT helperDendritic cellsLymph nodesLN cellsCell subsetsImmunomodulatory effectsLymphoid organsTh2 cellsImmune response
2007
Marginal Zone B-Cell Depletion Impairs Murine Host Defense against Borrelia burgdorferi Infection
Belperron AA, Dailey CM, Booth CJ, Bockenstedt LK. Marginal Zone B-Cell Depletion Impairs Murine Host Defense against Borrelia burgdorferi Infection. Infection And Immunity 2007, 75: 3354-3360. PMID: 17470546, PMCID: PMC1932939, DOI: 10.1128/iai.00422-07.Peer-Reviewed Original ResearchConceptsT-cell-independent antibodiesCell-depleted miceSplenic CD4Cell depletionPathogen burdenSplenic T cell responsesHost defenseT-cell activation markersC3H/HeJ miceImmunoglobulin M titersInfected control miceMurine host defensePathogen-specific IgMT cell responsesMarginal zone B cellsBlood-borne antigensBlood-borne pathogensWeeks of infectionB cell subsetsImmune mouse serumBorrelia burgdorferi infectionImportant host defenseSevere arthritisActivation markersControl mice
2001
CD4+ T Helper 1 Cells Facilitate Regression of Murine Lyme Carditis
Bockenstedt L, Kang I, Chang C, Persing D, Hayday A, Barthold S. CD4+ T Helper 1 Cells Facilitate Regression of Murine Lyme Carditis. Infection And Immunity 2001, 69: 5264-5269. PMID: 11500394, PMCID: PMC98634, DOI: 10.1128/iai.69.9.5264-5269.2001.Peer-Reviewed Original ResearchConceptsAlphabeta T-cell-deficient miceT cell-deficient miceMurine Lyme carditisT cellsLyme carditisB cellsT helper 1 cellsAnti-inflammatory cytokines mRNA levelsTumor necrosis factor alphaBurgdorferi-specific antibodiesInfected control miceProminent macrophage infiltrateCell-mediated immunityT cell responsesT helper 1Murine Lyme borreliosisCytokine mRNA levelsNecrosis factor alphaAlphabeta T cellsPrincipal immune cellsMouse strain backgroundAdoptive transferAcute arthritisMacrophage infiltratesControl mice