2005
Infection-Induced Marginal Zone B Cell Production of Borrelia hermsii-Specific Antibody Is Impaired in the Absence of CD1d
Belperron AA, Dailey CM, Bockenstedt LK. Infection-Induced Marginal Zone B Cell Production of Borrelia hermsii-Specific Antibody Is Impaired in the Absence of CD1d. The Journal Of Immunology 2005, 174: 5681-5686. PMID: 15843569, DOI: 10.4049/jimmunol.174.9.5681.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialAntibody SpecificityAntigens, CD1Antigens, CD1dB-Lymphocyte SubsetsBorreliaBorrelia InfectionsDNA, BacterialGerminal CenterImmune SeraImmunity, InnateImmunization, PassiveImmunoglobulin MLymphocyte ActivationLymphocyte DepletionMiceMice, Inbred C57BLMice, KnockoutConceptsMZB cellsActivation markersPathogen burdenMouse serumAbsence of CD1dBlood-borne AgsCD1d-deficient micePathogen-specific IgMActivation marker expressionMarginal zone B cellsT cell helpImmune mouse serumWild-type miceCritical host defenseB cell productionB. hermsiiCD1d expressionSerum levelsCell helpPassive transferSpirochete burdenAb productionSpirochete Borrelia burgdorferiB cellsCell activation
2001
Natural Antibody Affects Survival of the SpirocheteBorrelia burgdorferi within Feeding Ticks
Belperron A, Bockenstedt L. Natural Antibody Affects Survival of the SpirocheteBorrelia burgdorferi within Feeding Ticks. Infection And Immunity 2001, 69: 6456-6462. PMID: 11553590, PMCID: PMC98781, DOI: 10.1128/iai.69.10.6456-6462.2001.Peer-Reviewed Original ResearchConceptsB cell-deficient miceNatural antibodiesControl miceConfocal immunofluorescence microscopySalivary glandsEarly host defenseBlood-sucking vectorsMammalian hostsFeeding ticksB. burgdorferi organismsNormal mouse serumTick midgutAbsence of exposureOuter surface protein AArthropod vectorsImmunofluorescence microscopyMammalian seraSurface protein ASpirochete Borrelia burgdorferiPolyclonal immunoglobulin MPathogen transmissionSpirochete burdenPassive transferBlood mealImmunoglobulin M