Leyuan Xu, PhD
Associate Professor TermCards
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Research
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2026
Aberrant p53 fuels macrophage immunoregulatory polarization and refractory clinical outcome in urothelial carcinoma
Ding Y, Jin K, Su X, Zhang L, Liu Z, Sun J, Wu Y, Shi J, Zeng H, Liu H, Zhu Y, Xu L, Wang Z, Chang Y, Zhang W, Xu J. Aberrant p53 fuels macrophage immunoregulatory polarization and refractory clinical outcome in urothelial carcinoma. Journal For ImmunoTherapy Of Cancer 2026, 14: e014408. PMID: 42161402, PMCID: PMC13202007, DOI: 10.1136/jitc-2025-014408.Peer-Reviewed Original ResearchConceptsTumor-associated macrophagesTumor immune microenvironmentTumor-Associated Macrophage InfiltrationUrothelial carcinomaP53 statusTP53Suppress CD4+ T cellsInfiltration of tumor-associated macrophagesImmunosuppressive tumor-associated macrophagesAssociated with worse overall survivalTumor-associated macrophage phenotypesCD4+ T cellsTumor-associated macrophage subsetsFlow cytometryAssociated with immune suppressionT cell landscapePlatinum-based chemotherapyTAM subsetsImmunosuppressive networkSuppressive subsetOverall survivalImmune landscapeImmune microenvironmentClinicopathological annotationImmune suppressionPeri-Arterial Neural Dissection During Adrenal Surgery Provides a Denervation-Like Benefit in Hypertension Control
Yi L, Cheng Y, Huang H, Pu Y, Huang J, Xing S, Fang C, Chen L, Xu D, Xu L. Peri-Arterial Neural Dissection During Adrenal Surgery Provides a Denervation-Like Benefit in Hypertension Control. Hypertension 2026, 83: e26495. PMID: 42059060, DOI: 10.1161/hypertensionaha.125.26495.Peer-Reviewed Original ResearchConceptsPostoperative blood pressure controlBlood pressure controlAdrenal surgeryDissection groupAntihypertensive medication usePressure controlNondissection groupDenervation-like effectAdrenocorticotropic hormone levelsMedication useMultivariate logistic regressionBlood urea nitrogenAssociated with lower oddsHypertension remissionRemission rateIntraoperative findingsSympathetic overactivityAdrenal functionDaily doseHypertensive patientsHypertension durationRenal arteryHormone levelsSurgeryPatients
2025
Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction
Reghuvaran A, Kumar A, Lin Q, Rajeevan N, Banu K, Sun Z, Shi H, Barsotti G, Tanvir E, Pell J, Perincheri S, Wei C, Bharathan B, Planoutene M, Eichmann A, Mas V, Zhang W, Cantley L, Xu L, Das B, He J, Menon M. Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction. Nature Communications 2025, 17: 1086. PMID: 41469391, PMCID: PMC12852734, DOI: 10.1038/s41467-025-67854-7.Peer-Reviewed Original ResearchConceptsROCK activitySmall molecule inhibitorsSHROOM3Wild typeAssociated with renal fibrosisCo-expressionRisk allelesTransgenic toolsPleiotropic effectsROCK inhibitionRho-kinaseOverexpressionCell linesPrecision therapeuticsFibroblast linesProfibrotic functionProfibrotic signalingMotifKidney diseaseEnhanced variantRenal fibrosisTubular cellsAlbuminuriaIn vivoMiceApplication of three-anatomical-plane dissection technique in the partial nephrectomy of renal cell carcinoma abutting the hilum gulf
Wang Q, Chen Y, Zhang G, Shen X, Gao Y, Wang H, Xu L, Jiang G, Fang C, Huang H, Xu D, Chen L. Application of three-anatomical-plane dissection technique in the partial nephrectomy of renal cell carcinoma abutting the hilum gulf. World Journal Of Surgical Oncology 2025, 23: 436. PMID: 41239455, PMCID: PMC12619286, DOI: 10.1186/s12957-025-04089-2.Peer-Reviewed Original ResearchConceptsPartial nephrectomyRenal functionMedian tumor diameterClavien-Dindo classificationRenal cell carcinomaFollow-up dataPatient demographic characteristicsRENAL scoreClavien-DindoSurgical marginsTumor diameterOncological characteristicsNo recurrenceRetroperitoneal approachTumor locationCell carcinomaPostoperative complicationsSurgical strategyLaparoscopic surgeryRuijin HospitalTumorSurgeryKidney parenchymaDissection techniquePatientsDiagnostic value of AHNAK2 immunohistochemical expression in papillary thyroid carcinoma: an immunohistochemical study
Zhang X, Chen L, Deng M, Liang H, Jiang D, Wang H, Liu Y, Zhang R, Xu L, Liu J, Sujie A, Xu C, Liu Y, Hou Y. Diagnostic value of AHNAK2 immunohistochemical expression in papillary thyroid carcinoma: an immunohistochemical study. Diagnostic Pathology 2025, 20: 123. PMID: 41188896, PMCID: PMC12584262, DOI: 10.1186/s13000-025-01723-1.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaAHNAK nucleoprotein 2Follicular thyroid carcinomaBRAF V600EFollicular adenomaHBME-1Thyroid carcinomaThyroid tumorsThyroid peroxidaseCyclin D1Thyroid cancerGalectin-3Diagnostic roleDiagnostic valueNon-invasive follicular thyroid neoplasmPapillary-like nuclear featuresFollicular thyroid neoplasmMalignant thyroid tumorsProtein familyThyroid neoplasmsImmunohistochemical expressionPathological diagnosisIHC panelImmunohistochemical markersMalignant tumorsRetraction Note: The circular RNA circfarsa sponges microRNA-330-5p in tumor cells with bladder cancer phenotype
Fang C, Huang X, Dai J, He W, Xu L, Sun F. Retraction Note: The circular RNA circfarsa sponges microRNA-330-5p in tumor cells with bladder cancer phenotype. BMC Cancer 2025, 25: 1613. PMID: 41120911, PMCID: PMC12538769, DOI: 10.1186/s12885-025-15198-2.Peer-Reviewed Original ResearchEngineering polyamidoamine dendrimer nanoparticles for targeted drug delivery to proximal tubular cells after renal ischemia/reperfusion injury
Li X, Cantley L, Xu L. Engineering polyamidoamine dendrimer nanoparticles for targeted drug delivery to proximal tubular cells after renal ischemia/reperfusion injury. Journal Of Controlled Release 2025, 388: 114323. PMID: 41101700, PMCID: PMC12548566, DOI: 10.1016/j.jconrel.2025.114323.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPT cellsGlomerular filtration barrierProximal tubulesPost-ischemia/reperfusion injuryTreatment of acute kidney injuryTargeted deliveryTherapeutic agentsDendrimer nanoparticlesEffective therapeutic optionRenal ischemia/reperfusion injuryDelivery of therapeutic agentsTargeted delivery of therapeutic agentsPro-inflammatory gene expressionFiltration barrierProximal tubular cellsTubular epithelial cellsUninvolved organsCell-specific drug deliveryRenal functionGene expressionTherapeutic optionsKidney injurySingle doseMice 7Mutational landscape of glomus tumor and clinical application of genomic profiling based on next-generation sequencing technology
Deng M, Wang H, Pan W, Luo R, Li X, Abuduwaili A, Xu L, Zhang X, Su J, Huang J, Xu C, Hou Y. Mutational landscape of glomus tumor and clinical application of genomic profiling based on next-generation sequencing technology. Pathology - Research And Practice 2025, 275: 156230. PMID: 40976119, DOI: 10.1016/j.prp.2025.156230.Peer-Reviewed Original ResearchConceptsSomatic single nucleotide variantsNext-generation sequencing technologiesNext-generation sequencingCopy number variationsMolecular genetic characteristicsMutational landscapeGlomus tumorGenetic characteristicsSingle nucleotide variantsPathway enrichment analysisApplication of genomic profilingEpithelial-mesenchymal transition pathwayG-A transitionNucleotide variantsSequencing technologiesNumber variationsGenetic mutational landscapeGene typesFrequent mutation typeDiagnosis of GTBRAF V600E mutationEnrichment analysisMutated genesClinical applicationPrecision diagnosisCPZ
Deng M, Luo R, Chen L, Wang H, Huang W, Song Q, Jiang D, Xu L, Su J, Xu C, Hou Y. CPZ. The American Journal Of Surgical Pathology 2025, 49: 711-729. PMID: 40189907, PMCID: PMC12165467, DOI: 10.1097/pas.0000000000002393.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntigens, NeoplasmArginaseBile Duct NeoplasmsBile Ducts, IntrahepaticBiomarkers, TumorCarcinoma, HepatocellularCell DifferentiationCholangiocarcinomaDiagnosis, DifferentialFemaleHumansImmunohistochemistryLiver NeoplasmsMaleMiddle AgedPredictive Value of TestsTissue Array AnalysisConceptsHep Par 1Carboxypeptidase ZHepatocellular carcinomaTissue microarrayPAR-1Arg-1Intrahepatic cholangiocarcinomaImmunohistochemical stainingDifferential diagnosisCombined detectionCases of solid tumorsDifferential diagnosis of hepatocellular carcinomaNormal tissuesDiagnosis of hepatocellular carcinomaRoutine surgical pathology practiceMetastatic liver tumorsPositive expression rateSurgical pathology practiceNormal liver tissuesMetallopeptidase familySolid tumorsLiver tumorsTumor tissuesPositive expressionAdjunctive toolLoss of SWI/SNF complex expression (SMARCA4, SMARCA2, SMARCB1, ARID1A) is associated with dMMR in primary adenocarcinoma of jejunum and ileum: A clinicopathological and molecular analysis based on the Chinese population
Deng M, Luo R, Wang H, Abuduwaili A, Jiang D, Zhang X, Xu L, Zhang X, Niu Z, Su J, Xu C, Hou Y. Loss of SWI/SNF complex expression (SMARCA4, SMARCA2, SMARCB1, ARID1A) is associated with dMMR in primary adenocarcinoma of jejunum and ileum: A clinicopathological and molecular analysis based on the Chinese population. Pathology - Research And Practice 2025, 269: 155891. PMID: 40101550, DOI: 10.1016/j.prp.2025.155891.Peer-Reviewed Original ResearchConceptsPrimary small-bowel adenocarcinomaAmplification-refractory mutation systemPIK3CA gene mutationsARID1A lossGene mutationsPrimary adenocarcinomaHigh-throughput sequencing technologyAssociated with lymphatic invasionNRAS gene mutationsChromatin Remodeling ComplexKRAS gene mutationsMolecular genetic testingSmall bowel adenocarcinomaLoss of expressionSequencing technologiesRemodeling complexARID1A proteinLymphatic invasionFemale predominancePoor prognosisBowel adenocarcinomaUnivariate analysisSWI/SNF complexPIK3CA inhibitorsARID1A
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