2013
Systemic retinoids in the management of ichthyoses and related skin types
DiGiovanna JJ, Mauro T, Milstone LM, Schmuth M, Toro JR. Systemic retinoids in the management of ichthyoses and related skin types. Dermatologic Therapy 2013, 26: 26-38. PMID: 23384018, PMCID: PMC3884695, DOI: 10.1111/j.1529-8019.2012.01527.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSkin typeHigh-dose vitaminMainstay of therapyTeratogenic side effectsSystemic retinoidsTerm retinoidsCareful surveillanceLimit toxicityEffective therapyDemonstrated efficacySide effectsMucous membranesVitamin ASevere ichthyosisSynthetic retinoidsEarly useRetinoidsTherapyVariety of agesSynthetic derivativesEfficacyTreatmentLimited usefulnessAcetretinEtretinate
2011
An appraisal of oral retinoids in the treatment of pachyonychia congenita
Gruber R, Edlinger M, Kaspar RL, Hansen CD, Leachman S, Milstone LM, Smith FJ, Sidoroff A, Fritsch PO, Schmuth M. An appraisal of oral retinoids in the treatment of pachyonychia congenita. Journal Of The American Academy Of Dermatology 2011, 66: e193-e199. PMID: 21601946, DOI: 10.1016/j.jaad.2011.02.003.Peer-Reviewed Original ResearchConceptsOral retinoidsOral retinoid treatmentPachyonychia congenitaAdverse effectsRetinoid treatmentVisual analog pain scaleSatisfaction scoresCareful dose titrationPainful plantar keratodermaAnalog pain scaleRetrospective cross-sectional surveyCross-sectional study designOverall satisfaction scoreRisk/benefit analysisCross-sectional surveyPotential adverse effectsPlantar painDose titrationPain scalePain changeClinical scoresNail changesPatient's perspectivePlantar keratodermaNail dystrophy
2005
Isotretinoin does have an adverse effect on bone mineral density
Milstone LM, Insogna KL, Leachman SA. Isotretinoin does have an adverse effect on bone mineral density. Journal Of The American Academy Of Dermatology 2005, 53: 181. PMID: 15965453, DOI: 10.1016/j.jaad.2005.03.025.Commentaries, Editorials and Letters
2002
Is retinoid-induced osteopenia reversible?
Milstone AM, Milstone LM. Is retinoid-induced osteopenia reversible? JAMA Dermatology 2002, 138: 1516-7. PMID: 12437467, DOI: 10.1001/archderm.138.11.1516-a.Commentaries, Editorials and Letters
1999
Bone Densities in Patients Receiving Isotretinoin for Cystic Acne
Leachman SA, Insogna KL, Katz L, Ellison A, Milstone LM. Bone Densities in Patients Receiving Isotretinoin for Cystic Acne. JAMA Dermatology 1999, 135: 961-965. PMID: 10456346, DOI: 10.1001/archderm.135.8.961.Peer-Reviewed Original ResearchConceptsCystic acneBone densityWard's triangleCalcium metabolismHealthy control subjectsYoung menIsotretinoin useOral isotretinoinPatient groupControl subjectsMean changeHealthy volunteersControl groupAcnePatientsMeasurable alterationsIsotretinoinFurther studiesOsteoporosisDecreased densityRetinoidsMetabolismMenBoneDirect effect
1982
Premature epiphyseal closure in a child receiving oral 13-cis-retinoic acid
Milstone L, McGuire J, Ablow R. Premature epiphyseal closure in a child receiving oral 13-cis-retinoic acid. Journal Of The American Academy Of Dermatology 1982, 7: 663-666. PMID: 6958690, DOI: 10.1016/s0190-9622(82)70148-3.Peer-Reviewed Original ResearchThe influence of retinoids on cultivated human keratinocytes
McGuire J, Fedarko N, Johanssen E, LaVigne J, Lyons G, Milstone L, Osber M. The influence of retinoids on cultivated human keratinocytes. Journal Of The American Academy Of Dermatology 1982, 6: 630-639. PMID: 6175669, DOI: 10.1016/s0190-9622(82)70052-0.Peer-Reviewed Original ResearchConceptsInfluence of retinoidsFetal bovine serumStratified squamous epitheliumTrans retinoic acidInteraction of keratinocytesSquamous epitheliumBovine serumVitamin AVitamin A.Cultured keratinocytesHuman keratinocytesRetinoidsKeratinocytesEagle's mediumSerumKeratin polypeptidesFormation of coloniesHigh levels