1995
Keratinocytes differentiate in response to inhibitors of deoxyribonucleotide synthesis
Schwartz P, Barnett S, Milstone L. Keratinocytes differentiate in response to inhibitors of deoxyribonucleotide synthesis. Journal Of Dermatological Science 1995, 9: 129-135. PMID: 7772575, DOI: 10.1016/0923-1811(94)00370-t.Peer-Reviewed Original Research
1992
Methotrexate induces differentiation of human keratinocytes.
Schwartz P, Barnett S, Atillasoy E, Milstone L. Methotrexate induces differentiation of human keratinocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 594-598. PMID: 1731329, PMCID: PMC48285, DOI: 10.1073/pnas.89.2.594.Peer-Reviewed Original ResearchConceptsEffect of methotrexateAbility of methotrexateProliferation of keratinocytesProportion of cellsMarkers of differentiationHuman epidermal keratinocytesMethotrexateTherapeutic actionEpidermal keratinocytesMarked increaseHuman keratinocytesKeratinocytesEnvelope proteinSDS/PAGE profilesInvolucrin synthesisNormal cellsTerminal differentiationTissue homeostasisThymine deoxyribonucleotidesDifferentiationCellsPsoriasisCell morphologyReproducible changesDose