2019
Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice
El-Hassar L, Song L, Tan WJT, Large CH, Alvaro G, Santos-Sacchi J, Kaczmarek LK. Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice. Journal Of Neuroscience 2019, 39: 4797-4813. PMID: 30936239, PMCID: PMC6561694, DOI: 10.1523/jneurosci.0839-18.2019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAuditory PathwaysAuditory PerceptionBrain StemCochlear NucleusElectrophysiological PhenomenaEvoked Potentials, Auditory, Brain StemFemaleFragile X Mental Retardation ProteinFragile X SyndromeHydantoinsIn Vitro TechniquesMaleMiceMice, KnockoutPatch-Clamp TechniquesPyridinesShaw Potassium ChannelsConceptsAuditory brainstem responseWild-type animalsRepetitive firingABR wave ICurrent-clamp recordingsAuditory brainstem nucleiVoltage-clamp recordingsHigh-frequency firingSingle action potentialFragile X syndromeTrapezoid bodyBrainstem nucleiBrainstem responseMedial nucleusAuditory brainstemAuditory nerveWave IWave IVAction potentialsSensory stimuliKv3.1 channelsCentral processingMental retardation proteinHigh sound levelsMice
2005
Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels
Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, von Hehn CA, Whim MD, Yang B. Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels. Hearing Research 2005, 206: 133-145. PMID: 16081004, DOI: 10.1016/j.heares.2004.11.023.Peer-Reviewed Original ResearchConceptsAnteroventral cochlear nucleusPotassium channelsAuditory pathwayAction potentialsCentral auditory pathwayVoltage-dependent potassium channelsMammalian auditory pathwayAmount of neurotransmitterProtein phosphorylationMNTB neuronsGene expressionBushy cellsPrincipal neuronsTrapezoid bodyCochlear nucleusIntrinsic excitabilityMedial nucleusVoltage-dependent channelsFiring patternsNeuronsAmplitude of currentsKv1 familySound stimuliLong-term modulationSound localization
2001
Localization of two high‐threshold potassium channel subunits in the rat central auditory system
Li W, Kaczmarek L, Perney T. Localization of two high‐threshold potassium channel subunits in the rat central auditory system. The Journal Of Comparative Neurology 2001, 437: 196-218. PMID: 11494252, DOI: 10.1002/cne.1279.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAuditory PathwaysCochlear NucleusFemaleGene ExpressionGeniculate BodiesImmunohistochemistryIn Situ HybridizationInferior ColliculiNeuronsNeuropeptidesOligonucleotide ProbesOlivary NucleusPotassium ChannelsPotassium Channels, Voltage-GatedRatsRats, Sprague-DawleyRNA, MessengerShaw Potassium ChannelsConceptsAuditory neuronsKv3.1 mRNAPotassium channelsMost auditory neuronsBrainstem auditory neuronsRat central auditory systemAction potential thresholdSubpopulation of neuronsCentral auditory systemLateral superior oliveRat auditory systemAuditory systemVoltage-sensitive potassium channelsRapid deactivation kineticsPotassium channel subunitsTrapezoid bodyRat brainstemMedial nucleusVentral nucleusLateral lemniscusTerminal arborizationsSynaptic inputsAuditory nucleiSuperior oliveChannel expression
1999
Shaw‐like potassium currents in the auditory rhombencephalon throughout embryogenesis
Hendriks R, Morest D, Kaczmarek L. Shaw‐like potassium currents in the auditory rhombencephalon throughout embryogenesis. Journal Of Neuroscience Research 1999, 58: 791-804. PMID: 10583910, DOI: 10.1002/(sici)1097-4547(19991215)58:6<791::aid-jnr6>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsPotassium currentNucleus magnocellularisOutward currentsWhole-cell patch recordingsInitial transient componentTransient outward currentsEarly neuronal developmentEarly neuronal differentiationHigh activation thresholdFirst synapsesAuditory nucleiPatch recordingsPotassium channel genesSynaptic functionCharacteristic response propertiesSynapses formNeuronal developmentNeuronal differentiationActivation thresholdDevelopmental appearanceTetraethylammoniumMagnocellularisEarly ageChannel genesNeuroblastsRole in neuronal cell migration for high‐threshold potassium currents in the chicken hindbrain
Hendriks R, Morest D, Kaczmarek L. Role in neuronal cell migration for high‐threshold potassium currents in the chicken hindbrain. Journal Of Neuroscience Research 1999, 58: 805-814. PMID: 10583911, DOI: 10.1002/(sici)1097-4547(19991215)58:6<805::aid-jnr7>3.0.co;2-v.Peer-Reviewed Original ResearchConceptsChannel blockersPotassium currentWhole-cell patch-clamp recordingsPotassium conductanceN-type calcium channelsPotassium channelsHigh-threshold potassium currentsCalcium channel blockersSensitive potassium channelsPotassium channel blockerPatch-clamp recordingsTetraethylammonium chlorideChronic blockadeNovel potassium channelNeuronal cell migrationTEA exposureCalcium channelsClamp recordingsEmbryonic neuronsSynaptic functionOutward currentsNeuronal migrationElectrical excitabilityMigratory activityIndividual neuroblasts
1998
Activation of Kv3.1 channels in neuronal spine-like structures may induce local potassium ion depletion
Wang L, Gan L, Perney T, Schwartz I, Kaczmarek L. Activation of Kv3.1 channels in neuronal spine-like structures may induce local potassium ion depletion. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 1882-1887. PMID: 9465111, PMCID: PMC19207, DOI: 10.1073/pnas.95.4.1882.Peer-Reviewed Original ResearchConceptsSpine-like structuresIon channelsMembrane structureMembrane compartmentsVesicle compartmentKv3.1 channelsBulk cytoplasmElectron immunomicroscopyCHO cellsPostsynaptic membraneVesiclesMembrane patchesSpine-like protrusionsNeuronal membrane structurePotassium channel Kv3.1Channel Kv3.1CellsComplete inactivationInactivationCompartmentsRapid depletionCentral nervous systemSlow refillingSynaptic stimulationNeuronal structures
1997
Localization of a high threshold potassium channel in the rat cochlear nucleus
Perney T, Kaczmarek L. Localization of a high threshold potassium channel in the rat cochlear nucleus. The Journal Of Comparative Neurology 1997, 386: 178-202. PMID: 9295146, DOI: 10.1002/(sici)1096-9861(19970922)386:2<178::aid-cne2>3.0.co;2-z.Peer-Reviewed Original ResearchConceptsCochlear nucleusBushy cellsKv3.1 mRNAKv3.1 channelsPotassium channelsDorsal cochlear nucleusRat cochlear nucleusVentral cochlear nucleusLarge synaptic potentialsTypes of neuronsProximal dendritesSynaptic potentialsAxon terminalsStained neuronsUnmyelinated axonsAuditory neuronsNeuronal firingOctopus cellsMultipolar cellsGiant cellsKv3.1 proteinNeuronsKv3.1Situ hybridizationImmunolabeling