1992
Hyperosmotic media inhibit voltage-dependent calcium influx and peptide release in Aplysia neurons
Loechner K, Knox R, Connor J, Kaczmarek L. Hyperosmotic media inhibit voltage-dependent calcium influx and peptide release in Aplysia neurons. The Journal Of Membrane Biology 1992, 128: 41-52. PMID: 1323684, DOI: 10.1007/bf00231869.Peer-Reviewed Original ResearchConceptsBag cell neuronsCell neuronsAction potentialsVoltage-dependent calcium influxVoltage-dependent calcium currentsPotassium-induced depolarizationIntracellular calcium levelsCalcium indicator dyeEffect of hyperosmolalityHyperosmotic mediumCalcium currentCalcium influxFura-2Calcium levelsPeptide secretionCalcium entryAfterdischargesBrief stimulationNeuroactive peptidesNeuronsSecretory propertiesAplysia neuronsHigh potassiumPeptide releaseRelease of peptides
1988
Inositol trisphosphate releases intracellularly stored calcium and modulates ion channels in molluscan neurons
Fink L, Connor J, Kaczmarek L. Inositol trisphosphate releases intracellularly stored calcium and modulates ion channels in molluscan neurons. Journal Of Neuroscience 1988, 8: 2544-2555. PMID: 2470874, PMCID: PMC6569530, DOI: 10.1523/jneurosci.08-07-02544.1988.Peer-Reviewed Original ResearchConceptsBag cell neuronsCell neuronsIntracellular calciumAction potentialsFluorescent calcium indicator fura-2Inositol trisphosphateCalcium indicator fura-2Intracellular calcium levelsIndicator fura-2Non-neuronal cellsCell-attached patch-clamp techniquePatch-clamp techniqueMicroinjection of inositolCultured bag cell neuronsHydrolysis of phosphoinositidesCalcium-containing mediumElectrophysiological effectsInjection of inositolFura-2Calcium levelsExtracellular calciumIsolated neuronsMolluscan neuronsCytosolic calciumTransient hyperpolarization