2006
A Store-Operated Ca2+ Influx Pathway in the Bag Cell Neurons of Aplysia
Kachoei BA, Knox RJ, Uthuza D, Levy S, Kaczmarek LK, Magoski NS. A Store-Operated Ca2+ Influx Pathway in the Bag Cell Neurons of Aplysia. Journal Of Neurophysiology 2006, 96: 2688-2698. PMID: 16885525, PMCID: PMC2894935, DOI: 10.1152/jn.00118.2006.Peer-Reviewed Original ResearchMeSH KeywordsAnilidesAnimalsAplysiaCalcium Channel BlockersCalcium ChannelsCalcium SignalingElectrophysiologyEnzyme InhibitorsImidazolesIn Vitro TechniquesIndicators and ReagentsIndolesInositol 1,4,5-TrisphosphateLanthanumMacrocyclic CompoundsMembrane PotentialsNeuronsNickelOxazolesRyanodine Receptor Calcium Release ChannelThapsigarginThiadiazolesConceptsBag cell neuronsCell neuronsCyclopiazonic acidCPA-sensitive storesSmooth muscle cell lineAbsence of extracellularCultured bag cell neuronsRyanodine receptor agonistATPase inhibitorReceptor blockersReceptor agonistNeuropeptide secretionXestospongin CMuscle cell lineInflux pathwayIntracellular storesNonneuronal cellsAcidic storesElevated intracellularNeuronsStore depletionAfterdischargesCell linesBafilomycin AEntry pathway
2001
Aplysia Ror Forms Clusters on the Surface of Identified Neuroendocrine Cells
McKay S, Hislop J, Scott D, Bulloch A, Kaczmarek L, Carew T, Sossin W. Aplysia Ror Forms Clusters on the Surface of Identified Neuroendocrine Cells. Molecular And Cellular Neuroscience 2001, 17: 821-841. PMID: 11358481, DOI: 10.1006/mcne.2001.0977.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAmino Acid SequenceAnimalsAntibody SpecificityAplysiaBase SequenceCaenorhabditis elegans ProteinsCell CompartmentationCells, CulturedCloning, MolecularGanglia, InvertebrateImmunohistochemistryMolecular Sequence DataNeuronsNeurosecretory SystemsReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase-like Orphan ReceptorsReceptors, Cell SurfaceRNA, MessengerConceptsBag cell neuronsNeuroendocrine bag cell neuronsROR receptorsCultured bag cell neuronsRegulation of growthReceptor tyrosine kinasesMarine mollusk Aplysia californicaPeripheral neuronal processesMollusk Aplysia californicaCellular polarityFunctional domainsTyrosine kinaseIntracellular organellesCell surfaceProteinNeuroendocrine cellsKinaseAplysia californicaRelease sitesNeuronal processesOrganellesNeuronal populationsForm clustersGanglionic neuropilReceptors
1989
Inhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia
Conn P, Strong J, Kaczmarek L. Inhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia. Journal Of Neuroscience 1989, 9: 480-487. PMID: 2918372, PMCID: PMC6569798, DOI: 10.1523/jneurosci.09-02-00480.1989.Peer-Reviewed Original Research
1988
Inositol trisphosphate releases intracellularly stored calcium and modulates ion channels in molluscan neurons
Fink L, Connor J, Kaczmarek L. Inositol trisphosphate releases intracellularly stored calcium and modulates ion channels in molluscan neurons. Journal Of Neuroscience 1988, 8: 2544-2555. PMID: 2470874, PMCID: PMC6569530, DOI: 10.1523/jneurosci.08-07-02544.1988.Peer-Reviewed Original ResearchConceptsBag cell neuronsCell neuronsIntracellular calciumAction potentialsFluorescent calcium indicator fura-2Inositol trisphosphateCalcium indicator fura-2Intracellular calcium levelsIndicator fura-2Non-neuronal cellsCell-attached patch-clamp techniquePatch-clamp techniqueMicroinjection of inositolCultured bag cell neuronsHydrolysis of phosphoinositidesCalcium-containing mediumElectrophysiological effectsInjection of inositolFura-2Calcium levelsExtracellular calciumIsolated neuronsMolluscan neuronsCytosolic calciumTransient hyperpolarization