1988
Inositol trisphosphate releases intracellularly stored calcium and modulates ion channels in molluscan neurons
Fink L, Connor J, Kaczmarek L. Inositol trisphosphate releases intracellularly stored calcium and modulates ion channels in molluscan neurons. Journal Of Neuroscience 1988, 8: 2544-2555. PMID: 2470874, PMCID: PMC6569530, DOI: 10.1523/jneurosci.08-07-02544.1988.Peer-Reviewed Original ResearchConceptsBag cell neuronsCell neuronsIntracellular calciumAction potentialsFluorescent calcium indicator fura-2Inositol trisphosphateCalcium indicator fura-2Intracellular calcium levelsIndicator fura-2Non-neuronal cellsCell-attached patch-clamp techniquePatch-clamp techniqueMicroinjection of inositolCultured bag cell neuronsHydrolysis of phosphoinositidesCalcium-containing mediumElectrophysiological effectsInjection of inositolFura-2Calcium levelsExtracellular calciumIsolated neuronsMolluscan neuronsCytosolic calciumTransient hyperpolarization
1983
Calcium entry causes a prolonged refractory period in peptidergic neurons of Aplysia
Kaczmarek L, Kauer J. Calcium entry causes a prolonged refractory period in peptidergic neurons of Aplysia. Journal Of Neuroscience 1983, 3: 2230-2239. PMID: 6631477, PMCID: PMC6564640, DOI: 10.1523/jneurosci.03-11-02230.1983.Peer-Reviewed Original ResearchConceptsOnset of afterdischargeProlonged refractory periodBag cell clustersBag cell neuronsCumulative depolarizationRefractory periodNatural refractorinessCell neuronsCalcium entryAction potentialsConcentration of ionophoreExtracellular tetraethylammonium ionsRepetitive intracellular stimulationPeptidergic bag cell neuronsPleuroabdominal connectivesCell clustersCalcium-deficient mediumAdenylate cyclase activatorCalcium-containing mediumMean durationPeptidergic neuronsAbdominal ganglionAfterdischargesBrief trainsIntracellular stimulation