2022
KCNJ8/ABCC9-containing K-ATP channel modulates brain vascular smooth muscle development and neurovascular coupling
Ando K, Tong L, Peng D, Vázquez-Liébanas E, Chiyoda H, He L, Liu J, Kawakami K, Mochizuki N, Fukuhara S, Grutzendler J, Betsholtz C. KCNJ8/ABCC9-containing K-ATP channel modulates brain vascular smooth muscle development and neurovascular coupling. Developmental Cell 2022, 57: 1383-1399.e7. PMID: 35588738, DOI: 10.1016/j.devcel.2022.04.019.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsBrainKATP ChannelsMiceMuscle, Smooth, VascularMyocytes, Smooth MuscleNeurovascular CouplingSulfonylurea ReceptorsZebrafishConceptsK-ATP channel functionVascular smooth muscle cell differentiationChannel functionSmooth muscle cell differentiationMuscle cell differentiationVascular smooth muscle developmentSmooth muscle developmentVSMC developmentHuman central nervous system disordersMuscle developmentVSMC differentiationCentral nervous system disordersCell differentiationChemical inhibitionVoltage-dependent calcium channelsATP-sensitive potassium channelsFunction mutationsCell progenitorsK-ATP channelsCerebral blood flowCell culture modelMolecular causesNervous system disordersIntracellular CaVasoconstrictive capacity
2015
Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes
Hill RA, Tong L, Yuan P, Murikinati S, Gupta S, Grutzendler J. Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes. Neuron 2015, 87: 95-110. PMID: 26119027, PMCID: PMC4487786, DOI: 10.1016/j.neuron.2015.06.001.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsCerebral blood flowBlood flowCapillary pericytesArteriolar smooth muscle cellsBlood flow regulationRegional blood flowNormal brain functionSmooth muscle actinSmooth muscle cell contractilityMuscle cell contractilityPericyte constrictionIschemic brainBrain ischemiaMicrovascular occlusionNeurovascular couplingMicrovascular diametersWhisker stimulationMuscle actinMuscle cellsBrain functionMajor causePathological conditionsPericytesVascular tree