2016
Stroke Treatment Academic Industry Roundtable Recommendations for Individual Data Pooling Analyses in Stroke
Lees K, Khatri P, Alexandrov A, Bivard A, Boltze J, Broderick J, Campbell B, Creighton F, Fiorella D, Furlan A, Gorelick P, Hess D, Kim W, Latour L, Liebeskind D, Luby M, Lyden P, Lynch J, Marshall R, Menon B, Muir K, Palesch Y, Peng H, Pryor K, Mocco J, Rasmussen P, Sacco R, Schwamm L, Smith E, Solberg Y, Vagal A, Warach S, Wechsler L, Wintermark M, Yoo A, Zander K. Stroke Treatment Academic Industry Roundtable Recommendations for Individual Data Pooling Analyses in Stroke. Stroke 2016, 47: 2154-2159. PMID: 27406108, PMCID: PMC4961517, DOI: 10.1161/strokeaha.116.012966.Peer-Reviewed Original ResearchMeSH KeywordsClinical Trials as TopicHumansMeta-Analysis as TopicResearch DesignStatistics as TopicStrokeConceptsPooled analysisClinical implicationsClinical trial findingsIndividual patient dataPooled findingsPrespecified subgroupsOngoing trialsStroke trialsTrial findingsTreatment strategiesClinical careIndividual drugsPooling analysisTrial teamSuch drugsClass effectSevere disabilityTrial resultsPatient dataAnalysis planTrialsStatistical adjustmentTreatment effects
2008
Quantitative Assessment of Core/Penumbra Mismatch in Acute Stroke
Schaefer P, Barak E, Kamalian S, Gharai L, Schwamm L, Gonzalez R, Lev M. Quantitative Assessment of Core/Penumbra Mismatch in Acute Stroke. Stroke 2008, 39: 2986-2992. PMID: 18723425, DOI: 10.1161/strokeaha.107.513358.Peer-Reviewed Original ResearchConceptsCT perfusionPatient selectionInfarct coreAcute middle cerebral artery strokeMiddle cerebral artery strokePreferred imaging methodStroke clinical trialsAcute strokeArtery strokeStroke trialsTrial enrollmentClinical trialsLesion volumeMR perfusionIschemic regionBlood volumeTime abnormalitiesVolume thresholdLesion sizeQuantitative CTPerfusionAdvanced MRCT coverageLesionsMR diffusion