2020
Thrombolysis beyond 4.5 h in Acute Ischemic Stroke
Etherton M, Gadhia R, Schwamm L. Thrombolysis beyond 4.5 h in Acute Ischemic Stroke. Current Neurology And Neuroscience Reports 2020, 20: 35. PMID: 32607627, DOI: 10.1007/s11910-020-01055-1.Peer-Reviewed Original ResearchConceptsUnknown symptom onsetSymptom onsetAcute ischemic stroke patientsImproved long-term outcomesSalvageable brain tissueIntravenous thrombolytic therapyPlacebo-controlled trialAcute ischemic strokeIschemic stroke patientsLong-term outcomesDWI-FLAIR mismatchAlteplase treatmentSummaryIn patientsIschemic strokeStroke onsetAcute settingRecent FindingsIn recent yearsStroke patientsThrombolytic therapySalvageable tissueReviewThe purposeIndividualized approachStroke lesionsPatientsBrain tissue
2002
Anatomy of Stroke, Part I
Caviness V, Makris N, Montinaro E, Sahin N, Bates J, Schwamm L, Caplan D, Kennedy D. Anatomy of Stroke, Part I. Stroke 2002, 33: 2549-2556. PMID: 12411641, DOI: 10.1161/01.str.0000036083.90045.08.Peer-Reviewed Original ResearchConceptsMCA territoryVolumetric analysisDistribution of infarctsTopography of infarctionTreatment of strokePerfusion-weighted imagingCorrelation of outcomesEmbolic strokeAcute eventClinical correlatesUnderlying pathophysiologyVascular territoriesLesion volumeStroke lesionsClinical diagnosisStrokeTherapeutic agentsMRINeuroanatomic structuresInfarctsTopographic patternsInvolvementPotential benefitsPerfusion compartmentsInfarction