Donor tissue-specific exosome profiling enables noninvasive monitoring of acute rejection in mouse allogeneic heart transplantation
Habertheuer A, Korutla L, Rostami S, Reddy S, Lal P, Naji A, Vallabhajosyula P. Donor tissue-specific exosome profiling enables noninvasive monitoring of acute rejection in mouse allogeneic heart transplantation. Journal Of Thoracic And Cardiovascular Surgery 2018, 155: 2479-2489. PMID: 29499866, DOI: 10.1016/j.jtcvs.2017.12.125.Peer-Reviewed Original ResearchConceptsEarly acute rejectionDonor heartsAcute rejectionHeart transplantationStudy armsImmunologic rejectionMaintenance armHeterotopic heart transplantation modelAllogeneic heart transplantationTime pointsHeart transplantation modelHeterotopic heart transplantationAbsence of rejectionNovel biomarker platformDevelopment of biomarkersNoninvasive monitoringTransplant heartCardiac allograftsImmunocompetent recipientsAllograft monitoringImmunodeficient recipientsRecipient circulationTransplantation modelDay 1Total plasma