1997
Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo.
Young L, Renfu Y, Russell R, Hu X, Caplan M, Ren J, Shulman G, Sinusas A. Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo. Circulation 1997, 95: 415-22. PMID: 9008459, DOI: 10.1161/01.cir.95.2.415.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportDogsFluorescent Antibody TechniqueGlucose Transporter Type 1Glucose Transporter Type 4HeartIntracellular MembranesMonosaccharide Transport ProteinsMuscle ProteinsMyocardial IschemiaMyocardiumRegional Blood FlowSarcolemmaSubcellular FractionsTissue Distribution
1996
Glucose metabolism distal to a critical coronary stenosis in a canine model of low-flow myocardial ischemia.
McNulty PH, Sinusas AJ, Shi CQ, Dione D, Young LH, Cline GC, Shulman GI. Glucose metabolism distal to a critical coronary stenosis in a canine model of low-flow myocardial ischemia. Journal Of Clinical Investigation 1996, 98: 62-69. PMID: 8690805, PMCID: PMC507401, DOI: 10.1172/jci118778.Peer-Reviewed Original ResearchConceptsLow-flow ischemiaCoronary stenosisIschemic myocardiumIschemic regionLow-flow myocardial ischemiaCritical coronary stenosisExogenous glucoseOxidative substrateMyocardial ischemiaIntact dogsGlucose metabolismNonischemic regionsClinical observationsCanine modelGlucose utilizationIschemiaBiochemical measurementsMyocardial regionsRate of incorporationIntracellular metabolismTricarboxylic acid cycle fluxStenosisMyocardiumGlucoseGlucose-derived pyruvate