Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size
Johnson MB, Sun X, Kodani A, Borges-Monroy R, Girskis KM, Ryu SC, Wang PP, Patel K, Gonzalez DM, Woo YM, Yan Z, Liang B, Smith RS, Chatterjee M, Coman D, Papademetris X, Staib LH, Hyder F, Mandeville JB, Grant PE, Im K, Kwak H, Engelhardt JF, Walsh CA, Bae BI. Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size. Nature 2018, 556: 370-375. PMID: 29643508, PMCID: PMC6095461, DOI: 10.1038/s41586-018-0035-0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBiological EvolutionCalmodulin-Binding ProteinsCentrosomeCerebral CortexDisease Models, AnimalFemaleFerretsGene DeletionGene EditingGene Expression Regulation, DevelopmentalGene Knockout TechniquesGerm-Line MutationHumansMaleMiceMicrocephalyNerve Tissue ProteinsNeural Stem CellsOrgan SizeTranscription, GeneticConceptsVentricular radial glial cellsEvolutionary mechanismsRadial glial cellsOuter radial gliaHuman primary microcephalyProtein sequence homologyAbnormal spindle-like microcephalyCerebral cortical sizeGlial cellsCortical sizeUndifferentiated cell typesNeural progenitor cellsRadial gliaASPM proteinCerebral cortical expansionMicrocephaly genesDivergent functionsGenome editingSequence homologyDifferentiated progenitorsOuter subventricular zoneCortical expansionPrimary microcephalyCell typesGermline knockout