2018
Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size
Johnson MB, Sun X, Kodani A, Borges-Monroy R, Girskis KM, Ryu SC, Wang PP, Patel K, Gonzalez DM, Woo YM, Yan Z, Liang B, Smith RS, Chatterjee M, Coman D, Papademetris X, Staib LH, Hyder F, Mandeville JB, Grant PE, Im K, Kwak H, Engelhardt JF, Walsh CA, Bae BI. Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size. Nature 2018, 556: 370-375. PMID: 29643508, PMCID: PMC6095461, DOI: 10.1038/s41586-018-0035-0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBiological EvolutionCalmodulin-Binding ProteinsCentrosomeCerebral CortexDisease Models, AnimalFemaleFerretsGene DeletionGene EditingGene Expression Regulation, DevelopmentalGene Knockout TechniquesGerm-Line MutationHumansMaleMiceMicrocephalyNerve Tissue ProteinsNeural Stem CellsOrgan SizeTranscription, GeneticConceptsVentricular radial glial cellsEvolutionary mechanismsRadial glial cellsOuter radial gliaHuman primary microcephalyProtein sequence homologyAbnormal spindle-like microcephalyCerebral cortical sizeGlial cellsCortical sizeUndifferentiated cell typesNeural progenitor cellsRadial gliaASPM proteinCerebral cortical expansionMicrocephaly genesDivergent functionsGenome editingSequence homologyDifferentiated progenitorsOuter subventricular zoneCortical expansionPrimary microcephalyCell typesGermline knockout
2005
ROC-based assessments of 3D cortical surface-matching algorithms
Bansal R, Staib LH, Whiteman R, Wang YM, Peterson BS. ROC-based assessments of 3D cortical surface-matching algorithms. NeuroImage 2005, 24: 150-162. PMID: 15588606, DOI: 10.1016/j.neuroimage.2004.08.054.Peer-Reviewed Original Research
2004
Altered Interhemispheric Connectivity in Individuals With Tourettes Disorder
Plessen KJ, Wentzel-Larsen T, Hugdahl K, Feineigle P, Klein J, Staib LH, Leckman JF, Bansal R, Peterson BS. Altered Interhemispheric Connectivity in Individuals With Tourettes Disorder. American Journal Of Psychiatry 2004, 161: 2028-2037. PMID: 15514403, DOI: 10.1176/appi.ajp.161.11.2028.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAttention Deficit Disorder with HyperactivityCase-Control StudiesCerebral CortexComorbidityCorpus CallosumCross-Sectional StudiesFunctional LateralityHumansMagnetic Resonance ImagingMaleNeuronal PlasticityObsessive-Compulsive DisorderPrefrontal CortexSeverity of Illness IndexTourette SyndromeConceptsCorpus callosum sizeCallosum sizeTourette's disorderCorpus callosumCerebral hemispheresComparison subjectsCross-sectional case-control studyMidsagittal corpus callosum areaCorpus callosum areaCase-control studyEffects of medicationAge 30 yearsCortical inhibitory interneuronsHigh-resolution magnetic resonanceHealthy comparison subjectsMajor commissureComorbid illnessesTic symptomsOrbitofrontal cortical volumeCortical volumeInhibitory interneuronsInterhemispheric connectivityInhibitory inputsTic severityPrior evidenceGeometric strategies for neuroanatomic analysis from MRI
Duncan JS, Papademetris X, Yang J, Jackowski M, Zeng X, Staib LH. Geometric strategies for neuroanatomic analysis from MRI. NeuroImage 2004, 23: s34-s45. PMID: 15501099, PMCID: PMC2832750, DOI: 10.1016/j.neuroimage.2004.07.027.Peer-Reviewed Original ResearchConceptsApplied mathematical approachWhite matter fiber tracksStatistical estimationMathematical approachFunction-structure analysisMagnetic resonance imagesEvolution strategyGeometric constraintsImage processingIntersubject registrationRich setGeometric strategyOngoing workData setsUse of levelsCommon spaceNeuroanatomic analysisSetRegistrationFiber tracksHuman brainResonance imagesInformationSegmentationEstimation
1999
Segmentation and measurement of the cortex from 3-D MR images using coupled-surfaces propagation
Zeng X, Staib L, Schultz R, Duncan J. Segmentation and measurement of the cortex from 3-D MR images using coupled-surfaces propagation. IEEE Transactions On Medical Imaging 1999, 18: 927-937. PMID: 10628952, DOI: 10.1109/42.811276.Peer-Reviewed Original ResearchConceptsImage-derived informationEasy initializationAutomatic segmentationEfficient segmentationMR imagesChallenging problemFinal representationManual segmentationThree-dimensional MR imagesSegmentationComputational efficiencyOutermost thin layerSuch problemsImagesTight couplingNew approachConvoluted natureRepresentationGeometric measurementsInitializationImplementationSulcal foldsBrain anatomyInformationConstraints