2002
Reduced volume of orbitofrontal cortex in major depression
Bremner JD, Vythilingam M, Vermetten E, Nazeer A, Adil J, Khan S, Staib LH, Charney DS. Reduced volume of orbitofrontal cortex in major depression. Biological Psychiatry 2002, 51: 273-279. PMID: 11958777, DOI: 10.1016/s0006-3223(01)01336-1.Peer-Reviewed Original ResearchConceptsMajor depressionOrbitofrontal cortexOrbitofrontal cortical volumeCortical volumeArea 32Area 24Brodmann's area 32Recent postmortem studiesWhole brain volumeSymptoms of depressionBrodmann's area 24Magnetic resonance imagingFrontal cortical regionsFunctional neuroimaging studiesSubcallosal gyrusDepressed patientsPostmortem studiesCortical subregionsComparison subjectsBrain volumePatientsResonance imagingCortical regionsCortexNeuroimaging studies
2001
Regional Brain and Ventricular Volumes in Tourette Syndrome
Peterson BS, Staib L, Scahill L, Zhang H, Anderson C, Leckman JF, Cohen DJ, Gore JC, Albert J, Webster R. Regional Brain and Ventricular Volumes in Tourette Syndrome. JAMA Psychiatry 2001, 58: 427-440. PMID: 11343521, DOI: 10.1001/archpsyc.58.5.427.Peer-Reviewed Original ResearchConceptsParieto-occipital regionsTourette syndromeTic symptomsCerebral volumeVentricular volumePathophysiology of TST subjectsWhite matter portionsThalamo-cortical circuitrySignificant inverse associationRegional cerebral volumesHigh-resolution anatomical magnetic resonance imagesStandard anatomical landmarksSex differencesAge-related findingsDorsal prefrontal regionsRegional brainCortico-striatoHealthy childrenHealthy controlsInverse associationHealthy subjectsOccipital volumeTS groupCortical regions