2017
Neferine, is not inducer but blocker for macroautophagic flux targeting on lysosome malfunction
Xu T, Singh D, Liu J, Li H, Peng S, Rizzolo LJ, Wang SB. Neferine, is not inducer but blocker for macroautophagic flux targeting on lysosome malfunction. Biochemical And Biophysical Research Communications 2017, 495: 1516-1521. PMID: 29197576, DOI: 10.1016/j.bbrc.2017.11.169.Peer-Reviewed Original ResearchMeSH KeywordsAntioxidantsAutophagyBenzylisoquinolinesDose-Response Relationship, DrugHEK293 CellsHeLa CellsHumansLysosomesMetabolic Flux AnalysisMicrotubule-Associated ProteinsConceptsLC3-IIMultiple pharmacological effectsAMPK/mTORNeferine treatmentKnockdown of ATG5Pharmacological effectsCancer cellsNeferineStrong inducerAutophagic fluxCathepsin DPhagocytic cargoLysosome maturationLysosome malfunctionExposureMacroautophagic fluxInducerMaturationAdaptor proteinArrhythmiasBlockersCancer
2007
Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier.
Rizzolo LJ, Chen X, Weitzman M, Sun R, Zhang H. Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier. Molecular Vision 2007, 13: 1259-73. PMID: 17679949.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBlood-Retinal BarrierCell Cycle ProteinsChick EmbryoCluster AnalysisCollagenExtracellular MatrixGene Expression ProfilingIntercellular JunctionsLamininMembrane ProteinsMicrotubule-Associated ProteinsMyosinsOligonucleotide Array Sequence AnalysisPhagocytosisPigment Epithelium of EyeProtein SubunitsProteinsReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTranscription, GeneticConceptsPattern of expressionExtensive remodelingAffymetrix microarray chipsCell-cell junctionsSignal transduction pathwaysExtracellular matrix interactionsAdherens junction proteinsTranscellular ion transportCell surface receptorsGenomic approachesEntire genomeGene OntologyTransduction pathwaysSTEM softwareZO-3Biological pathwaysFunctional clusteringMatrix interactionsExtracellular matrixSurface receptorsJunctional complexesMicroarray chipContinuous remodelingFalse discovery rateAffymetrix software